Skin-Active Peptide Sequence for Penetration and Stability Balance
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Solution Overview
Problem
Existing peptides for skin improvement, such as those promoting collagen biosynthesis and fibroblast proliferation, face challenges in effectively entering target tissues and maintaining stability due to size and short half-life, limiting their efficacy in improving skin conditions like wrinkles and elasticity.
Innovation Solution
A peptide with a specific amino acid sequence (SEQ ID NO: 1) is synthesized with chemical modifications for enhanced stability and specificity, formulated into cosmetic and pharmaceutical compositions to promote fibroblast proliferation and increase dermal extracellular matrix expression, including collagen, fibronectin, and elastin.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing peptides are used to promote collagen biosynthesis and fibroblast proliferation, then skin improvement activity is achieved, but the peptides fail to effectively enter target tissues and maintain stability due to size and short half-life
Solution Approach 1:
The patent modifies the peptide sequence parameters by selecting specific amino acid residues (SEQ ID NO: 1) that optimize both biological activity and stability. The peptide consists of 10 amino acids with specific sequences that have been determined to provide optimal balance between penetration capability and stability maintenance.
Solution Approach 2:
The peptide is designed as a short sequence (10 amino acids) rather than a long protein, segmenting the molecular structure to improve penetration through the skin barrier while maintaining sufficient biological activity for fibroblast proliferation and collagen synthesis promotion.
2Reliability
If existing peptides are used to promote collagen biosynthesis and fibroblast proliferation, then skin improvement activity is achieved, but the peptides have short half-life limiting their efficacy
Solution Approach 1:
The patent optimizes the peptide sequence parameters to extend half-life while maintaining skin improvement activity. The specific amino acid sequence (SEQ ID NO: 1) has been selected to provide optimal balance between penetration capability and duration of action in promoting fibroblast proliferation and collagen biosynthesis.
3Ease of operation
If peptide size is reduced to improve penetration, then target tissue entry is enhanced, but the peptide may lack sufficient stability and half-life
Solution Approach 1:
The patent optimizes the peptide sequence parameters to achieve the optimal balance between size for penetration and length for stability. The 10 amino acid sequence (SEQ ID NO: 1) provides sufficient length to maintain stability and half-life while remaining short enough to penetrate target tissues effectively.
Data Source
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AI summary
The present application relates to a peptide having the activity of improving the state of skin, and uses thereof, and provides a peptide consisting of the amino acid sequence of SEQ ID NO: 1, and a cosmetic composition for improving skin condition including the peptide as an active ingredient.