Skin Electrical Pulse Stimulation for Blood Glucose Stabilization
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Solution Overview
Problem
Current treatments for type 2 diabetes, including drug therapies, cause discomfort and have limited effectiveness in stabilizing blood glucose fluctuations and reducing inflammation, while existing electrical stimulation devices are ineffective in humans.
Innovation Solution
An electrical stimulation system generating specific electric pulse combinations, delivered through electrodes on the skin, with frequencies ranging from 1 to 20,000 Hz, to stabilize blood glucose and reduce inflammation by reducing C-reactive protein and fibroblast growth factor 21 expression.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If drug therapy is used to reduce hyperglycemia, then blood glucose levels can be reduced, but patient comfort deteriorates due to side effects such as hypoglycemia
Solution Approach 1:
The patent replaces chemical drug therapy with an electrical stimulation system that uses electrical pulses to stimulate the skin. This substitution eliminates the harmful side effects of pharmaceuticals (such as hypoglycemia) while still achieving the therapeutic goal of stabilizing blood glucose levels through non-invasive electrical stimulation.
Solution Approach 2:
The patent employs specific electrical stimulation parameters including frequencies ranging from 1 to 20,000 Hz across three frequency groups, duty cycles greater than or equal to 50%, and square waveforms. These optimized parameters enable effective blood glucose stabilization without the harmful side effects associated with drug therapy.
2Ease of operation
If conventional electrical stimulation devices are used, then electrical stimulation can be applied, but effectiveness in treating human diabetes deteriorates due to insufficient blood glucose stabilization
Solution Approach 1:
The patent significantly improves therapeutic effectiveness by optimizing electrical stimulation parameters: using frequencies from 1 to 20,000 Hz divided into three groups, duty cycles ≥50%, and square waveforms. These specific parameter combinations produce effective blood glucose stabilization and inflammation reduction that conventional devices fail to achieve.
Solution Approach 2:
The patent employs periodic electrical pulse stimulation with specific frequency groups and duty cycles. The pulsed nature of the stimulation, with defined on/off ratios and frequency sequences, creates effective periodic action that stabilizes blood glucose levels more effectively than continuous or conventional intermittent stimulation.
3Reliability
If complex frequency combinations are used, then blood glucose stabilization improves, but device complexity increases
Solution Approach 1:
The patent divides the complex frequency spectrum into three distinct frequency groups (first: 10-20,000 Hz, second: 1-30 Hz, third: 5-30 Hz). Each group contains multiple single-phase pulse groups that can be independently controlled. This segmentation simplifies the generation of complex frequency combinations by organizing them into manageable, modular groups with specific therapeutic functions.
Solution Approach 2:
The patent implements dynamic electrical stimulation by sequentially outputting different frequency groups over time, with each group having adjustable duration (e.g., first group: 2300-2350 seconds, second group: 900-1000 seconds, third group: 320-400 seconds). This dynamic sequencing allows the device to deliver complex therapeutic protocols while maintaining operational simplicity through automated program control.
Data Source
AI summary
The present invention relates to an electrical stimulation system and a method thereof. The electrical stimulation system includes an electrical stimulation generator and at least one electrode structure. The electrical stimulation generator is used to generate an electric pulse combination which is transmitted to the skin of an individual through the electrode structure for stabilizing blood glucose fluctuations and reducing inflammation.