Sample Collection Kit with Movable Sleeve Valve
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Solution Overview
Problem
Existing biological sample collection systems often require specialized personnel and controlled environments, making it inconvenient for untrained individuals to collect and preserve samples effectively, especially in remote or geographically diverse locations, and existing kits rely on inexperienced users for sample deposition, leading to potential errors in sample preservation.
Innovation Solution
A biological sample collection system comprising a sample collection vessel, a sealing cap with a selectively movable sleeve valve, and an outer sleeve that frictionally engages with the inner vessel, allowing for easy sample collection and preservation by unskilled users, as the sleeve valve opens to dispense reagents into the sample collection chamber when the sealing cap is engaged, ensuring proper preservation without the need for specialized equipment or trained personnel.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If specialized equipment and controlled laboratory conditions are used for sample collection and preservation, then sample preservation quality is improved, but device complexity and operational difficulty increase
Solution Approach 1:
The collection system is divided into separate functional components: a collection vessel for sample deposition, a sealed reagent container for preservation chemistry, and a mixing mechanism. This segmentation allows each component to be optimized independently while maintaining overall reliability, enabling untrained users to handle simpler individual parts rather than complex integrated systems.
Solution Approach 2:
Preservation reagents are pre-loaded and sealed within the collection system before sample collection. The reagents are prepared in advance at controlled conditions during manufacturing, then stored in a sealed state. When the user collects the sample, the pre-prepared reagents are automatically mixed with the sample without requiring the user to perform complex preparation steps, thereby maintaining high preservation quality while simplifying user operation.
2Reliability
If controlled laboratory environments are required for sample collection, then sample preservation quality is improved, but ease of operation and accessibility decrease
Solution Approach 1:
The collection system is designed to perform preservation functions automatically once the sample is deposited. The system includes self-contained reagent containers that automatically dispense and mix preservation chemistry with the sample without requiring external laboratory equipment or controlled environmental conditions. This self-service capability allows untrained individuals to collect and preserve samples in any setting, from remote field locations to clinical offices.
Solution Approach 2:
The collection vessel integrates multiple functions into a single device: sample collection, reagent storage, automated mixing, and preservation. This multi-functional design eliminates the need for separate laboratory equipment and controlled environments, enabling the same system to be used effectively across diverse settings by untrained users while maintaining consistent sample preservation quality.
3Ease of operation
If untrained individuals perform sample deposition in self-collection systems, then ease of operation improves, but manufacturing precision and reliability of preservation decrease
Solution Approach 1:
The system pre-determines and pre-loads exact amounts of preservation reagents into sealed containers during manufacturing. The reagent quantities, concentrations, and mixing ratios are precisely controlled during production rather than requiring precise user measurement. This preliminary precision work eliminates the need for untrained users to perform accurate measurements while ensuring consistent preservation quality.
Solution Approach 2:
The system includes pre-prepared intermediate reagent formulations that are stable during storage and only become active upon contact with the sample. These intermediary reagent forms are manufactured with high precision under controlled conditions, then stored in a stable state. When the user simply deposits the sample, the pre-prepared intermediary reagents automatically react to provide precise preservation without requiring the user to handle or measure sensitive chemicals.
4Reliability
If immediate processing of biological samples is required, then sample quality is improved, but loss of time increases due to travel to collection centers
Solution Approach 1:
The collection system integrates sample collection, preservation reagent storage, and mixing functions into a single portable device. This multi-functional integration eliminates the need for separate laboratory processing steps and controlled environment facilities. Users can collect and immediately preserve samples in the field, then transport the preserved samples to laboratories at their convenience, significantly reducing time loss while maintaining sample quality.
Solution Approach 2:
The system performs preliminary preservation action at the moment of sample collection. Preservation reagents are pre-loaded and automatically mixed with the sample immediately upon deposition, stabilizing the sample before it leaves the collection site. This preliminary preservation prevents degradation during transport and storage, allowing samples to be collected in remote locations and processed later without compromising quality, thereby eliminating time loss associated with immediate laboratory processing.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system simplifies biological sample collection and preservation, reducing the likelihood of errors and costs associated with sample procurement, while increasing the geographic reach of sample collection areas without the need for established infrastructure or skilled personnel, allowing for accurate sample preservation for diagnostic or scientific analysis.
Implementation Method 1
An outer sleeve frictionally engages with the inner vessel while sliding translationally relative to the inner vessel between a first position and a second position
Data Source
AI summary
A sample collection system can include a sample collection vessel having a sample collection chamber with an opening configured to receive a sample into the sample collection chamber. The sample collection system can additionally include a selectively movable sleeve valve configured to associate with the opening of the sample collection chamber. The sample collection system can include a sealing cap that is configured to associate with the selectively movable sleeve valve and with the sample collection vessel. The sealing cap can include a reagent chamber having reagent(s) stored therein, and when the sealing cap is associated with the sample collection vessel, the selectively movable sleeve valve opens, dispensing the reagent(s) into the sample collection chamber. When the selectively moveable sleeve associates with the sample collection chamber, an outer sleeve slides relative to an inner vessel, opening the sleeve and dispensing reagent into the sample collection chamber.


