Intermediate Pumping Chamber With SMA Actuation for Precise Drug Dosing
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Solution Overview
Problem
Conventional drug delivery devices suffer from inaccuracies in delivering a fixed volume of liquid drug due to mechanical sticking or slipping of the pump mechanism, leading to under-or over-delivery issues and a lack of a simplified system for precise drug expulsion.
Innovation Solution
A wearable drug delivery device incorporating a reservoir, a delivery pump device with a chamber body, a sliding fluidic member, and a shape memory alloy wire to accurately draw and expel a liquid drug, utilizing a plunger and hard stop configuration to ensure precise dosing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a conventional plunger-based pump mechanism is used to expel liquid drug from the reservoir, then the device can deliver the liquid drug, but mechanical sticking or slipping occurs leading to inaccurate dosing
Solution Approach 1:
The patent replaces the conventional mechanical plunger-based pump mechanism with a shape memory alloy (SMA) wire-driven system. The SMA wire undergoes phase transformation under electrical stimulation to change length, directly actuating the sliding fluidic member without complex mechanical linkages. This substitution eliminates mechanical sticking and slipping issues while maintaining reliable dosing accuracy.
Solution Approach 2:
The patent utilizes the phase transformation property of shape memory alloy wire, which changes its length in response to temperature changes induced by electrical current. This parameter change (length contraction upon heating) directly drives the pumping action, providing precise and repeatable motion that eliminates the mechanical inaccuracies of conventional plunger systems.
2Reliability
If a conventional pump mechanism with multiple moving parts is used, then the liquid drug can be expelled, but the overall device size increases
Solution Approach 1:
The patent combines multiple functions into integrated components. The sliding fluidic member integrates the plunger function, valve function, and fluid pathway into a single movable component. The SMA wire directly actuates this integrated member, eliminating the need for separate linkages, springs, and mechanical transmission elements, thereby reducing overall device volume while maintaining reliable drug expulsion.
Solution Approach 2:
The patent employs a compact nested arrangement where the sliding fluidic member moves within the pump chamber, and the SMA wire is contained within or alongside these components. The plunger channel and flow orifice are integrated within the sliding fluidic member structure, creating a space-efficient configuration that minimizes device size.
3Volume of moving object
If a simplified pump system is used to reduce device size, then the overall dimensions decrease, but mechanical sticking or slipping may still occur
Solution Approach 1:
The patent replaces complex mechanical actuation systems with a direct SMA wire actuation mechanism. The phase transformation of the SMA wire provides smooth, controlled motion without the friction, backlash, or mechanical play that cause sticking and slipping in simplified mechanical systems. This maintains dosing precision while achieving device size reduction.
Solution Approach 2:
The patent exploits the reversible phase transition of shape memory alloy between austenite (high-temperature, contracted state) and martensite (low-temperature, extended state). This phase transition provides a clean, repeatable actuation cycle without mechanical wear or friction, ensuring dosing precision in a compact device configuration.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system enables accurate and reliable delivery of a set amount of liquid drug per pulse, reducing the overall size of the drug delivery device and minimizing mechanical inaccuracies.
Implementation Method 1
a shape memory alloy wire coupled to the sliding fluidic member. The shape memory alloy wire is operable to draw the liquid drug from the reservoir through the inlet port and into the pump chamber by pulling the sliding fluidic member and the plunger in a first direction
Data Source
AI summary
Disclosed are examples of devices, systems and techniques for delivering a liquid drug. An example delivery pump device may include a chamber body defining a pump chamber, an inlet valve to receive a liquid drug and a hard stop. A plunger configured with a plunger channel. A sliding fluidic member including a needle coupling, a flow orifice, a face seal and an anchor portion that may be movable within the pump chamber. A pump mechanism may be coupled to the anchor portion and operable to pull the anchor portion and the plunger toward the hard stop. Techniques may include determining a time to output a liquid drug from the delivery pump device; generating a control signal to actuate the delivery pump device; applying a control signal to the pump mechanism; determining that a control signal is to be removed from the pump mechanism; and delivering the liquid drug.


