Smear Preparing Apparatus Concentrated Buffer Dilution

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Solution Overview

Problem

Existing smear preparing apparatuses require frequent replacement and supply of large volumes of buffer solution, increasing user workload and consumption, especially in large facilities like medical examination centers.

Innovation Solution

A smear preparing apparatus and method that includes a buffer solution preparation unit to dilute highly-concentrated buffer solution, a diluted staining solution preparation unit to dilute staining solutions with the diluted buffer solution, and a stain unit to stain smear slides, reducing the frequency of buffer solution replacement and user workload by using a smaller amount of highly-concentrated buffer solution and storing diluted solutions for efficient reuse.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If a large volume of buffer solution is used to dilute staining solutions, then the frequency of replacing buffer solution increases, but the user workload during replacement increases

Engineering Contradiction:
Improvevolume of buffer solutionVSAvoiduser workload during replacement
Core Design Contradiction:
Quantity of substanceVSEase of operation

Solution Approach 1:

The patent changes the concentration parameter of the buffer solution from diluted to highly-concentrated form. By storing and using highly-concentrated buffer solution instead of diluted buffer solution, the volume required is significantly reduced, which in turn reduces the frequency of replacement and the user workload associated with handling large-volume tanks

Inventive Principle:
Principle #35Parameter changes

2Loss of time

If a large volume of buffer solution is stored in the apparatus, then the frequency of replacing buffer solution decreases, but the apparatus size and user burden increase

Engineering Contradiction:
Improvefrequency of buffer solution replacementVSAvoidvolume of buffer solution tank
Core Design Contradiction:
Loss of timeVSVolume of stationary object

Solution Approach 1:

The patent applies parameter change by switching from storing diluted buffer solution to storing highly-concentrated buffer solution. This concentration parameter change allows the same functional capacity to be achieved with a much smaller volume, thereby reducing tank size while maintaining acceptable replacement frequency

Inventive Principle:
Principle #35Parameter changes

3Reliability

If diluted buffer solution is used for staining, then the staining quality is maintained, but the consumption of buffer solution increases

Engineering Contradiction:
Improvestaining qualityVSAvoidconsumption of buffer solution
Core Design Contradiction:
ReliabilityVSLoss of substance

Solution Approach 1:

The patent implements preliminary action by pre-concentrating the buffer solution and performing dilution only at the point of use or just before the staining process. This ensures that the buffer solution is diluted to the appropriate concentration for staining while minimizing the total volume consumed, as the highly-concentrated form can be stored efficiently and diluted as needed

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The patent changes the concentration parameter of the buffer solution from diluted to highly-concentrated for storage and transport, then temporarily adjusts it to the required diluted state for the actual staining process. This parameter transformation allows maintaining staining quality while reducing overall consumption and waste

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Decreases the frequency of buffer solution replacement and reduces user workload by efficiently preparing and reusing diluted solutions, thereby minimizing the consumption of buffer solutions and maintaining consistent staining quality.

Implementation Method 1

a buffer solution preparation unit that prepares diluted buffer solution by diluting a highly-concentrated buffer solution

Methodology Applied
Scientific EffectDilution:

Implementation Method 2

a diluted staining solution preparation unit that prepares diluted staining solution by diluting a highly-concentrated staining solution with the diluted buffer solution

Methodology Applied
Scientific EffectDilution:

Data Source

PatentUS11073449B2Smear preparing apparatus and smear preparing method
Publication Date: 2021.07.27 SYSMEX CORP
  • US11073449B2 patent drawing
  • US11073449B2 patent drawing
  • US11073449B2 patent drawing

AI summary

A smear preparing apparatus includes: a smear unit that prepares a smear slide by smearing a sample on a slide; a buffer solution preparation unit that prepares diluted buffer solution by diluting a highly-concentrated buffer solution; a diluted staining solution preparation unit that prepares diluted staining solution by diluting a highly-concentrated staining solution with the diluted buffer solution; and a stain unit that stains the smear slide prepared by the smear unit with the diluted staining solution.