Snake Venom Composition for Rheumatoid Arthritis With Fewer Side Effects
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current treatments for rheumatoid arthritis, such as non-steroidal anti-inflammatory agents, cause side effects and are not effective in completely curing the autoimmune disease, and there is a need for more effective therapeutic agents.
Innovation Solution
A pharmaceutical, quasi-drug, food, and cosmetic composition comprising snake venom derived from Naja melanoleuca, extracted and fractionated using various methods, which can be administered orally or topically to treat rheumatoid arthritis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If non-steroidal anti-inflammatory agents are used to treat rheumatoid arthritis, then pain and inflammation symptoms are alleviated, but side effects occur in various organs such as gastrointestinal tract, kidney, heart, and liver
Solution Approach 1:
The patent changes the chemical composition parameter by replacing conventional non-steroidal anti-inflammatory agents with snake venom-derived peptides and proteins. This parameter change maintains anti-inflammatory effectiveness while eliminating the harmful side effects associated with traditional NSAIDs on gastrointestinal tract, kidney, heart, and liver
Solution Approach 2:
The patent converts the harmful toxins in snake venom into beneficial therapeutic agents through detoxification processes. The venom components that would normally be harmful are processed to retain anti-inflammatory and immunomodulatory activities while removing toxic effects, thus transforming a harmful substance into a safe and effective treatment for rheumatoid arthritis
2Reliability
If current anti-inflammatory treatments are used, then symptoms are temporarily alleviated, but the autoimmune disease cannot be completely cured
Solution Approach 1:
The patent employs immunomodulatory components from snake venom that regulate the immune system's feedback mechanisms. These components help restore proper immune tolerance and reduce autoimmune attacks on joints, addressing the root cause rather than merely suppressing symptoms temporarily. This feedback regulation may lead to long-term disease control and potentially prevent further joint destruction
Solution Approach 2:
The patent uses snake venom components that can prevent further joint damage and disability by modulating immune responses before irreversible damage occurs. The treatment aims to stop the progressive nature of rheumatoid arthritis by interfering with the autoimmune attack early, potentially preventing the need for more aggressive interventions later
Data Source
Figure 1~2
Figure 3~4
Figure 5~7
AI summary
The present invention relates to a pharmaceutical composition for preventing or treating rheumatoid arthritis, comprising snake venom derived from Agkistrodon piscivorus piscivorus or Naja melanoleuca, which are types of snakes, an extract thereof, or a fraction thereof; a quasi-drug composition; a food composition; a cosmetic composition; and a method of treating rheumatoid arthritis by using the composition. The snake venom derived from Agkistrodon piscivorus piscivorus or Naja melanoleuca of the present invention can improve, alleviate, or treat symptoms of rheumatoid arthritis, which is a kind of autoimmune diseases, and thus will be able to be widely used in the development of therapeutic agents for various autoimmune diseases including rheumatoid arthritis.