3D Printed SNEDDS Tablet for Metabolic Disorder Treatment
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Solution Overview
Problem
Current 3D printed medications face challenges with limited oral bioavailability due to inadequate aqueous solubility and dissolution rates, leading to significant drug loss during absorption, particularly for active pharmaceutical ingredients that do not reach commercialization.
Innovation Solution
A self-nanoemulsifying 3D printer ink composition incorporating glimepiride and rosuvastatin in a curcuma oil-based self-nanoemulsifying drug delivery system (SNEDDS) with specific surfactants, co-surfactants, and hydroxypropyl methylcellulose as a gelling agent, allowing for customizable drug release rates and enhanced bioavailability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If conventional 3D printed medications are used, then manufacturing flexibility and personalization are improved, but oral bioavailability deteriorates due to inadequate aqueous solubility and dissolution rates
Solution Approach 1:
The patent changes the physical and chemical parameters of the drug delivery system by incorporating SNEDDS technology, which transforms the drug formulation into a self-nanoemulsifying system. This changes the dissolution behavior and enhances aqueous solubility, thereby improving oral bioavailability while maintaining 3D printing personalization capabilities
Solution Approach 2:
The patent uses composite materials by combining curcuma oil with specific surfactants (Tween 80, Span 60) and co-surfactants (PEG 400, PEG 200) to create a SNEDDS system. This composite formulation enhances drug solubility and dissolution rate, resolving the bioavailability issue while preserving the advantages of 3D printed personalized medication
2Reliability
If SNEDDS system is incorporated to improve bioavailability, then aqueous solubility and dissolution rates are improved, but formulation complexity increases
Solution Approach 1:
The SNEDDS system is designed to be self-nanoemulsifying, meaning it automatically forms nanoemulsions upon contact with aqueous fluids in the body without requiring external energy input or complex delivery mechanisms. This self-service property simplifies the overall system while enhancing bioavailability
Solution Approach 2:
The patent utilizes phase transition phenomena where the oil-surfactant-co-surfactant mixture transitions from a macroemulsion or separate phases to a stable nanoemulsion system. This phase transition occurs spontaneously under mild conditions, enhancing drug solubility without requiring complex formulation processes
3Adaptability or versatility
If compartmentalized tablet structure is used for personalized drug release, then dose customization is improved, but manufacturing complexity increases
Solution Approach 1:
The patent divides the tablet into multiple compartments or layers, each containing different drugs or dosages. This segmentation allows for personalized dose customization while using 3D printing technology to manufacture the complex structure in a relatively simple, additive process
Solution Approach 2:
Different regions or compartments of the tablet are assigned different properties, such as varying drug concentrations, release rates, or compositions. This local quality approach enables personalized medication where each compartment is optimized for specific therapeutic needs, achieved through 3D printing's layer-by-layer construction capability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition significantly improves bioavailability and allows for personalized pharmaceutical treatment by customizing the dose and release behavior of glimepiride and rosuvastatin, enhancing therapeutic efficacy and reducing side effects.
Implementation Method 1
a self-nanoemulsifying 3D printer ink composition... curcuma oil based self-nanoemulsifying drug delivery system (SNEDDS)... significantly improves bioavailability
Implementation Method 2
self-nanoemulsifying drug delivery system (SNEDDS)... enhanced bioavailability having doses of glimepiride and/or rosuvastatin designed to be responsive to the individual patient's needs
Implementation Method 3
2-10% w/v of hydroxypropyl methylcellulose (HPMC) as a gelling agent... customizable drug release rates
Data Source
AI summary
Provided are a self-nanoemulsifying 3D printer ink composition and a method of using such composition to manufacture a 3D-printed tablet having compartmentalized active pharmaceutical ingredients. In particular, the 3D-printed tablet composition includes glimepiride and/or rosuvastatin in a curcuma oil based self-nanoemulsifying drug delivery system (SNEDDS). The disclosure also provides a method of treating a metabolic disorder or disease by administering a therapeutically effective amount of the 3D-printed tablet to a subject in need thereof.