SNP Microarray Profiling for Periodontitis Susceptibility Detection

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Solution Overview

Problem

Current methods fail to predict and effectively treat severe periodontitis and its associated conditions like Alzheimer's disease, as they lack a clinical phenotype to identify individuals susceptible to P. gingivalis and other periodontal diseases.

Innovation Solution

A diagnostic microarray device and kit that utilizes probes specific to SNPs in genes such as IL1A−889, IL1B+3954, IL1B−511, IL6−1363, IL10−597, IL10−1082, CD14−260, and COX2+8473 to determine a genetic phenotype for susceptibility to periodontitis and related diseases, followed by targeted therapeutic interventions.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If conventional diagnostic methods are used, then general disease detection is possible, but prediction and effective treatment of severe periodontitis and associated conditions like Alzheimer's disease cannot be achieved

Engineering Contradiction:

Improvedisease susceptibility prediction accuracyVSAvoidtreatment effectiveness

Core Design Contradiction:

Measurement precisionVSReliability

Solution Approach 1:

The invention segments the diagnostic approach by focusing on specific genetic markers (SNPs in IL1A, IL1B, IL6, IL10, CD14, and COX2 genes) rather than using general diagnostic methods. This segmentation allows for precise identification of individuals with high susceptibility to periodontitis and associated conditions, enabling targeted intervention strategies that improve both prediction accuracy and treatment reliability.

Inventive Principle:

Principle #1Segmentation

2Measurement precision

If genetic testing for multiple SNPs is performed, then accurate identification of genetic predisposition is achieved, but device complexity and testing cost increase

Engineering Contradiction:

Improvegenetic phenotype identification accuracyVSAvoidmicroarray device structure

Core Design Contradiction:

Measurement precisionVSDevice complexity

Solution Approach 1:

The microarray device is designed with multi-functionality to detect multiple SNP markers across different gene families (IL1A, IL1B, IL6, IL10, CD14, COX2) simultaneously. This universal design allows a single device to perform comprehensive genetic susceptibility assessment for periodontitis and associated conditions, achieving high measurement precision without requiring multiple separate testing systems, thereby managing device complexity through integrated functionality.

Inventive Principle:

Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The device accurately identifies genetic predisposition to severe periodontitis and associated conditions, enabling personalized treatment strategies to reduce disease progression and severity.

Implementation Method 1

Methodology Applied

Scientific EffectHybridization:

Data Source

PatentUS20260009082A1Devices, kits, and methods for determining increased susceptibility to and treatment and prevention of periodontitis, alzheimer’s disease, and other conditions

Publication Date: 2026.01.08 LEVINE MARTIN

AI summary

Diagnostic microarray devices, kits, and methods of treating or reducing the occurrence of various conditions or diseases are disclosed, wherein the conditions or diseases include (but are not limited to) periodontal disease, Alzheimer's disease, cardiovascular disease, arthritis, and adverse pregnancy outcomes. The devices, kits, and methods utilize an analysis of single nucleotide polymorphisms (SNPs) from various interleukins.