Sodium Bicarbonate Buffer for Local Anesthetic Duration
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Solution Overview
Problem
Current anesthetic agents provide limited duration of pain control, necessitating frequent administration and potential disruption of normal body functions, especially during and after surgical or dental procedures.
Innovation Solution
Administration of an inorganic or organic salt agent, such as sodium bicarbonate, to areas previously treated with regional or local anesthetics, altering the anesthetic to provide extended pain control by converting it into a slow or prolonged release form.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If conventional anesthetic agents are administered, then pain control is provided, but the duration of pain control is limited requiring frequent administration
Solution Approach 1:
The patent changes the pH parameter of the anesthetic solution by adding bicarbonate buffer to increase pH to 7.0-9.0, which converts the anesthetic to a slower-release form that extends duration of action from typically 1-2 hours to 4-8 hours or longer, reducing the frequency of administration required
2Reliability
If frequent anesthetic administration is performed, then pain control is maintained, but disruption of normal body functions increases
Solution Approach 1:
The patent applies preliminary action by adding bicarbonate buffer to the anesthetic solution before administration, which pre-modifies the anesthetic to have extended duration and reduced toxicity, thereby maintaining reliable pain control while minimizing the harmful effects of frequent administrations
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method extends pain control or relief for a measurable duration, reducing the need for frequent anesthetic administration and minimizing disruption of body functions during and after procedures.
Implementation Method 1
Administration of an inorganic or organic salt agent, such as a bicarbonate (e.g., sodium bicarbonate, 4.8%, pH 7.8-8.2), a buffered phosphated nitrated salt, to a patient that has previously been administered a regional or local anesthesia alters the regional or local anesthesia so as to provide or extend pain (chronic or acute) control in the patient.
Data Source
AI summary
Methods for providing post-operative pain control or relief to a patient are disclosed. Methods include, for example, administering bicarbonate to an area of a patient during a surgical or dental procedure, near completion of a surgical or dental procedure or immediately following a surgical or dental procedure, in an area previously administered or containing a regional or local anesthetic in an amount sufficient to provide the patient with pain control or relief for a period of time after the surgical or dental procedure.