Sodium Formate Antibiotic Sensitization for CRE Treatment
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Solution Overview
Problem
Current treatments for carbapenem-resistant Gram-negative bacteria, such as CRE, are limited by rising drug resistance rates and the lack of effective antibacterial combination therapies.
Innovation Solution
The use of sodium formate in combination with an aminoglycoside antibiotic, such as micronomicin, gentamicin, or amikacin, to enhance the sensitivity of drug-resistant bacteria to the antibiotic, thereby achieving an anti-infective effect.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If monotherapy with existing antibiotics is used to treat CRE infection, then treatment is simple, but drug resistance rate increases and treatment effectiveness decreases
Solution Approach 1:
The patent combines sodium formate with existing antibiotics (polymyxin, tigecycline, fosfomycin, carbapenems, or aminoglycosides) to create a combination therapy that maintains treatment simplicity while overcoming drug resistance. The sodium formate enhances the antibacterial activity of these drugs against CRE, allowing effective treatment without increasing complexity significantly.
Solution Approach 2:
The invention creates a composite therapeutic approach by combining sodium formate (an organic carboxylate salt) with conventional antibiotics. This composite formulation leverages the unique properties of sodium formate to restore antibiotic effectiveness against resistant bacteria, achieving reliable treatment outcomes.
2Reliability
If combination therapy with multiple antibiotics is used to treat CRE infection, then treatment effectiveness improves, but device complexity and treatment complexity increase
Solution Approach 1:
Instead of combining multiple complex antibiotics, the patent merges a single, simple substance (sodium formate) with one conventional antibiotic. This approach achieves effective combination therapy against CRE while minimizing treatment complexity, as sodium formate is a straightforward organic salt that does not require complex administration protocols.
3Reliability
If new antibiotics are developed to treat CRE infection, then drug resistance is overcome, but development time and cost increase
Solution Approach 1:
The patent applies preliminary action by using sodium formate to pre-condition or sensitize the bacterial targets, making existing antibiotics effective again. This approach bypasses the need for lengthy new drug development by preparing the system in advance to respond to conventional treatments.
Solution Approach 2:
The invention changes the chemical parameter landscape by introducing sodium formate, which alters the interaction between antibiotics and bacterial targets. This parameter change restores the effectiveness of existing drugs without requiring the time-consuming process of developing entirely new antibiotic molecules.
4Reliability
If high dose antibiotics are used to treat drug-resistant bacteria, then killing effect improves, but harmful effects and side effects increase
Solution Approach 1:
Sodium formate acts as an intermediary substance that enhances the bactericidal effectiveness of antibiotics at lower doses. It mediates between the antibiotic and the resistant bacteria, restoring drug sensitivity and enabling effective treatment at reduced antibiotic concentrations, thereby minimizing harmful side effects.
Data Source
AI summary
The present invention belongs to the technical field of biological medicine, and specifically relates to use of sodium formate in preparation of an anti-infective drug. The present invention has found through research that sodium formate can significantly increase the sensitivity of a bacterium to an antibiotic, so that the antibiotic that is originally ineffective or inefficient against a pathogenic bacterium becomes effective or efficient, thereby killing the bacterium and achieving an anti-infective effect. Sodium formate and an antibiotic are further prepared into an anti-infective composition, so that on the one hand, a significant anti-infective effect can be achieved under the condition of a low-concentration antibiotic, and on the other hand, the decreased use amount of the antibiotic can also significantly reduce the likelihood of a bacterium developing drug resistance; and sodium formate has been widely used in food and medicine with high safety.