Sodium Iodide And Catalase Compositions for Hydrogen Peroxide Breakdown

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Solution Overview

Problem

Existing treatments for oxidative stress-related diseases and conditions are inadequate, particularly in addressing the imbalance between reactive oxygen species production and the body's detoxification capacity, leading to cellular damage and inflammation.

Innovation Solution

A pharmaceutical composition comprising sodium iodide or catalase, optionally with a reducing agent, is administered to disrupt the oxidative stress cycle by catalyzing the decomposition of hydrogen peroxide into water and oxygen, thereby reducing oxidative stress and its associated effects.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional treatments for oxidative stress are used, then disease symptoms may be managed, but the underlying oxidative stress cycle and peroxide build-up cannot be effectively disrupted

Engineering Contradiction:

Improveeffectiveness of treatmentVSAvoidability to address oxidative stress imbalance

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent uses iodide ion as an intermediary substance that facilitates the decomposition of hydrogen peroxide through a catalytic cycle. The iodide ion mediates the conversion of peroxide into water and oxygen, effectively disrupting the oxidative stress cycle without being consumed in the process. This intermediary mechanism provides a reliable and versatile treatment approach for various oxidative stress-related conditions.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Reliability

If sodium iodide or catalase is administered to catalyze peroxide decomposition, then oxidative stress is reduced and disease progression is reversed or prevented, but the complexity of the pharmaceutical composition increases

Engineering Contradiction:

Improveability to disrupt oxidative stress cycleVSAvoidcomposition formulation complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent optimizes the concentration parameters of sodium iodide (0.001% to 10% by weight) and catalase (0.001% to 10% by weight) to achieve effective peroxide decomposition while maintaining formulation simplicity. By carefully controlling these concentration parameters, the invention achieves reliable disruption of the oxidative stress cycle without requiring complex multi-component formulations or sophisticated delivery systems.

Inventive Principle:

Principle #35Parameter changes

3Reliability

If reducing agents are added to the composition, then the therapeutic effect on oxidative stress is enhanced, but the manufacturing and formulation process becomes more complex

Engineering Contradiction:

Improvetherapeutic efficacyVSAvoidformulation process simplicity

Core Design Contradiction:

ReliabilityVSEase of manufacture

Solution Approach 1:

The patent employs reducing agents such as thiosulfate, vitamin C, or sodium bisulfite that act temporarily to enhance the therapeutic effect during treatment, then are metabolized or excreted by the body. These short-acting reducing agents provide enhanced therapeutic efficacy during the treatment period without requiring long-term stability or complex storage conditions, thereby simplifying the overall manufacturing and formulation process.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition effectively lessens oxidative stress, reversing or preventing diseases and conditions by breaking the self-reinforcing cycle of peroxide build-up, promoting cellular health and reducing inflammation.

Implementation Method 1

catalyzing the decomposition of hydrogen peroxide into water and oxygen

Methodology Applied

Scientific EffectCatalysis: Catalysis

Implementation Method 2

decomposition of hydrogen peroxide into water and oxygen

Methodology Applied

Scientific EffectDecomposition: Decomposition (biological)

Implementation Method 3

the reducing agent is thiosulfate, vitamin C, or sodium bisulfate

Methodology Applied

Scientific EffectRedox reactions: Redox Reactions

Data Source

PatentUS20250249035A1Compositions and methods for treating or preventing diseases associated with oxidative stress

Publication Date: 2025.08.07 CXL OPHTHALMICS LLC

AI summary

Methods and compositions for treating various indications by lessening oxidative stress in a patient are provided. A pharmaceutical composition comprises between about 0.001% to about 10.0%, or more specifically between about 0.015% to about 5%, sodium iodide or catalase by weight. The iodine ion or the catalase dissociates hydrogen peroxide into water and molecular oxygen to interrupt biological events that result in negative side effects. The pharmaceutical composition further comprises in some cases a reducing agent or various carrier materials. The pharmaceutical composition is in some cases formulated for a variety of delivery methods.