Sodium Silicate Coated Medical Guidewires
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Solution Overview
Problem
Existing medical guidewires face issues with delamination of PTFE coatings in vivo, which can be dangerous and life-threatening due to flaking, necessitating a safer and more effective coating solution that maintains necessary properties like rigidity, flexibility, corrosion resistance, and lubricity.
Innovation Solution
A coated medical guidewire with a substrate of stainless steel, surgical steel, or CoCrMo alloy, featuring a cured coating layer formed from an aqueous sodium silicate solution, applied through cleaning and curing processes to ensure a durable and non-flaking coating.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If a PTFE coating is applied to the guidewire to reduce friction, then lubricity is improved, but the coating may flake and delaminate in vivo causing safety issues
Solution Approach 1:
The patent changes the material parameter from PTFE to sodium silicate coating, which fundamentally alters the coating's properties. The sodium silicate coating provides similar lubricity while eliminating the flaking and delamination issues associated with PTFE, thereby improving reliability without sacrificing the friction-reducing benefit
Solution Approach 2:
The patent uses a composite coating system where sodium silicate serves as the base coating material. This composite approach allows the coating to combine multiple functions: friction reduction, corrosion resistance, and structural integrity, while avoiding the harmful flaking behavior of pure PTFE coatings
2Object-affected harmful factors
If a thick hydrophilic coating is applied to the distal end to cover coil gaps, then surface lubricity is improved, but the coating may delaminate and cause harm
Solution Approach 1:
The patent changes the coating material parameter from conventional hydrophilic polymers to sodium silicate. This material parameter change maintains the necessary surface lubricity for reducing friction while providing a coating that does not delaminate, thereby eliminating the harmful effect of flaking while preserving the beneficial lubricity
3Ease of operation
If a PTFE coating is applied to reduce catheter friction, then ease of operation is improved, but the coating flakes and creates safety risks
Solution Approach 1:
The patent changes the coating material from PTFE to sodium silicate, which maintains the ease of operation benefit for catheter glide while eliminating the harmful flaking effect. The sodium silicate coating provides sufficient lubricity for smooth catheter passage without creating safety risks through delamination
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The sodium silicate coating provides a durable, non-flaking solution that maintains the necessary properties for safe and effective medical procedures, reducing the risk of coating delamination and improving guidewire performance.
Implementation Method 1
subjecting the coated guidewire substrate to a temperature of at least 120° C. for a time sufficient to effect cure and form a coated medical guidewire
Implementation Method 2
a cured coating layer applied to the guidewire substrate (a). The cured coating layer is prepared from a curable film-forming composition comprising an aqueous solution of sodium silicate
Implementation Method 3
subjecting the coated guidewire substrate to a temperature of at least 120° C. for a time sufficient to effect cure
Data Source
AI summary
Coated medical guidewires are provided comprising: (a) a guidewire substrate comprising stainless steel, surgical steel, nitinol, or CoCrMo alloy; and (b) a cured coating layer applied to the guidewire substrate (a). The cured coating layer is prepared from a curable film-forming composition comprising an aqueous solution of sodium silicate. Also provided are methods of forming coated medical guidewires comprising: (a) cleaning a guidewire substrate; (b) contacting the guidewire substrate with a curable film-forming composition comprising an aqueous solution of sodium silicate to form a coating layer on the guidewire; and (c) subjecting the guidewire substrate and film forming composition to a temperature of at least 120° C. for a time sufficient to effect cure and form a coated medical guidewire.