Soft Capsule Film Stabilizing Tyndalized Bacteria Against Separation
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Solution Overview
Problem
Existing soft capsules face challenges in maintaining homogeneity and stability of insoluble ingredients like dead bacteria, particularly when using high-fat oils and surfactant-suspending agents, leading to separation and denaturation during high-temperature processes.
Innovation Solution
A soft capsule design with a capsule shell layer composed of a high-viscosity polymer material, such as gelatin, that stabilizes dead bacteria by preventing separation and sedimentation, ensuring homogeneity even with small amounts of these ingredients.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If surfactant-suspending agents are used to disperse insoluble ingredients, then homogeneity is improved, but heat-sensitive ingredients are destroyed or denatured due to high-temperature processing
Solution Approach 1:
The patent changes the temperature parameter during formulation from high temperature (60°C or higher) to room temperature or lower temperatures, allowing surfactant-suspending agents to function effectively without causing thermal denaturation of heat-sensitive ingredients like vitamins and herbal extracts
Solution Approach 2:
The patent introduces surfactant-suspending agents as intermediary substances that mediate between insoluble ingredients and the aqueous or oily base, enabling homogeneous dispersion without requiring high-temperature processing
2Stability of the object's composition
If high-fat oils and fats are used as surfactant-suspending agents, then homogeneity is improved, but stability deteriorates due to destruction of heat-sensitive ingredients
Solution Approach 1:
The patent changes the temperature parameter from high temperature (60°C or higher) to room temperature or lower, allowing the use of surfactant-suspending agents including high-fat oils and fats without causing thermal destruction of heat-sensitive ingredients
Solution Approach 2:
The patent uses readily available surfactant-suspending agents including high-fat oils and fats that can be easily incorporated into the formulation at low temperatures, providing effective homogenization without compromising ingredient stability
3Device complexity
If small amounts of solid pharmaceutically active ingredients are added, then formulation complexity is reduced, but homogeneity deteriorates due to separation and deposition over time
Solution Approach 1:
The patent introduces surfactant-suspending agents as intermediary substances that coat and stabilize small amounts of solid pharmaceutically active ingredients, preventing their separation and deposition over time while maintaining formulation simplicity
Solution Approach 2:
The patent changes the temperature parameter to low or room temperature processing, which prevents the separation and deposition of small amounts of solid ingredients by maintaining stable dispersion conditions throughout the product lifecycle
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The capsule shell layer maintains the homogeneity and stability of dead bacteria, preventing separation and denaturation, while allowing for the inclusion of functional oils without affecting their stability, and providing benefits like anti-inflammation and immunomodulation.
Implementation Method 1
a polymer material forming the capsule shell layer may have high viscosity. For example, the viscosity of the polymer material may be 8,000 to 20,000 cP at 60° C.
Implementation Method 2
dead bacteria which are stable in heat
Data Source
AI summary
The present invention relates to a soft capsule comprising tyndalized bacteria in a film. The soft capsule, according to the present invention, can secure homogeneity of the tyndalized bacteria in the film even with a trace amount of the tyndalized bacteria, and since functional ingredients and the tyndalized bacteria can be administered simultaneously, the advantages due to the functional ingredients and the advantages due to the tyndalized bacteria can be obtained simultaneously.