Soft Chewable Veterinary Tablets Without Oily Texture
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Solution Overview
Problem
Existing veterinary chewable compositions often have an oily or greasy texture due to the use of fats, oils, pre-gelatinized starches, and sugars, which can affect palatability and patient compliance, and are not efficiently produced using rotary tablet presses.
Innovation Solution
A stable, palatable soft chew composition is formulated without fats, oils, or pre-gelatinized starches, using a rotary tablet press to compress a blend of veterinary active ingredient, animal and non-animal based palatants, and veterinary acceptable excipients such as disintegrants, binders, humectants, and lubricants.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If fats, oils, pre-gelatinized starches, and sugars are used in veterinary chewable compositions, then palatability is improved, but the composition becomes oily and greasy
Solution Approach 1:
The invention removes fats, oils, pre-gelatinized starches, and sugars from the formulation entirely, replacing them with alternative excipients that provide necessary functional properties without creating oily or greasy textures. This extraction of problematic components resolves the contradiction by eliminating the source of the harmful texture while maintaining palatability through other means.
Solution Approach 2:
The invention changes the physical and chemical parameters of the formulation by using different excipient types with distinct properties. Instead of using lipids and sugars that create oily textures, the formulation employs water-soluble and fiber-based excipients that provide palatability through different mechanisms (flavor release, texture modulation) without the harmful oily feel.
2Ease of manufacture
If extrusion processes are used to prepare chewable compositions, then the composition can be formed, but production efficiency is reduced
Solution Approach 1:
The invention replaces the extrusion mechanical system with a rotary tablet press compression system. Instead of forcing material through dies under heat and pressure (extrusion), the formulation is compressed into tablets using high pressure applied through punches. This mechanical substitution enables more efficient production while achieving the desired chewable dosage form.
Solution Approach 2:
The invention changes the manufacturing parameters from extrusion conditions (temperature, shear force, die pressure) to compression parameters (compressive force, punch speed, tablet density). This parameter change allows the use of rotary tablet presses which have higher production speeds and better control over tablet properties, thereby improving productivity.
3Ease of operation
If conventional chewable formulations are used, then palatability is achieved, but stability and shelf-life are reduced
Solution Approach 1:
The invention extracts and removes unstable components such as fats, oils, and pre-gelatinized starches that are prone to oxidation, hydrolysis, and microbial growth. By eliminating these labile excipients, the formulation achieves enhanced stability and extended shelf-life while maintaining palatability through alternative excipients with better storage properties.
Solution Approach 2:
The invention uses a composite excipient system combining water-soluble binders, disintegrants, lubricants, and fiber materials that collectively provide both palatability and stability. This composite approach allows each component to contribute specific properties: some excipients enhance taste and texture, while others provide structural integrity and resistance to degradation during storage.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition achieves increased stability, shelf-life, and palatability, enhancing patient compliance by avoiding greasy textures and utilizing a rotary tablet press for efficient production.
Implementation Method 1
the granulation is compressed with a rotary tablet press
Data Source
AI summary
The present invention is directed to a soft chewable composition comprising or containing a therapeutically effective amount of a veterinary active agent, preferably a JAK inhibitor; an animal based palatant, a non-animal based palatant, a flavor modifier, and at least one veterinary acceptable excipient that is selected from at least one each of a disintegrant, binder, lubricant, humectant, and glidant; and wherein the soft chewable tablet is compressed with a rotary tablet press; and methods for treating or preventing cancer, asthma, atopic dermatitis, autoimmune disorders, pruritus associated with allergic dermatitis, allergies, and chronic respiratory disease in an animal.