Soft Tablet Manufacturing Process for Animal Oral Compositions
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current oral solid formulations for animals face challenges in treatment compliance due to poor palatability, difficulty in administration, and uneven dispersion of active ingredients, leading to incomplete dosing.
Innovation Solution
A process for preparing a solid composition, referred to as a 'soft tablet,' which involves mixing active ingredients and excipients to form wet granules, spreading them at room temperature, and then compressing them using a tablet press, resulting in a formulation that is more palatable, easier to handle, and allows for accurate dosing and bi- or quadrisectibility.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If soft chews are manufactured using forming or extrusion processes, then a unique shape and size can be achieved, but the active ingredient is not homogenously dispersed and the compositions remain friable requiring long maturation
Solution Approach 1:
The patent changes the manufacturing parameters by using a granulation process with controlled moisture content (15-25%) and specific compression forces, transforming the soft chew from a friable state requiring long maturation to a stable state ready for immediate packaging and storage
Solution Approach 2:
The patent performs preliminary granulation and compression actions before final packaging, creating a stable formulation that does not require extended maturation time while ensuring homogeneous dispersion of active ingredients throughout the soft chew matrix
2Ease of operation
If solid compositions are administered orally to animals, then treatment can be given without specialized equipment, but poor palatability and bad taste reduce treatment compliance
Solution Approach 1:
The patent applies local quality by incorporating palatable materials and flavors specifically into the soft chew formulation to improve animal acceptance, while maintaining the therapeutic efficacy of the active ingredients through controlled dispersion and dosing
Solution Approach 2:
The patent uses composite materials by combining active ingredients with palatable excipients, flavors, and carriers in a unified soft chew formulation that simultaneously provides therapeutic effect and animal palatability
3Reliability
If soft chews are made with high proportion of palatable ingredients including fats and flavors, then palatability is improved, but the composition cannot be divided into smaller doses for different animal weights
Solution Approach 1:
The patent applies segmentation by designing soft chews that can be physically divided into smaller doses, allowing the same palatable formulation to be adapted for different animal weights and sizes while maintaining the palatability and therapeutic efficacy of the active ingredients
4Ease of manufacture
If conventional tablet presses are used to compress granules, then production costs are reduced and equipment complexity is minimized, but the tablet may be too hard or too soft for optimal animal acceptance and handling
Solution Approach 1:
The patent changes the compression parameters by adjusting pressure, time, and granule moisture content during tablet formation, creating a tablet with optimal hardness that is neither too hard nor too soft, while using conventional equipment to maintain cost-effectiveness
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The 'soft tablet' formulation enhances treatment compliance by offering improved palatability, accurate dosing, ease of handling, and flexibility in size and shape, while reducing production costs and eliminating the need for elaborate equipment.
Implementation Method 1
mixing said at least one active ingredient and said at least one excipient in a granulator to obtain wet granules
Implementation Method 2
compressing granules obtained after step ii) with a tablet press
Data Source
AI summary
The present invention relates to a process for preparing a solid composition comprising at least one active ingredient and at least one excipient comprising: i) mixing said at least one active ingredient and said at least one excipient in a granulator to obtain wet granules; ii) spreading wet granules on a tray and let stand for 2 to 24 hours between 15 and 25° C.; iii) compressing granules obtained after step ii) with a tablet press; and iv) collecting the solid composition. The invention further relates a solid composition obtained by such process.