Sol-Gel Composition for Dermatitis Treatment
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Solution Overview
Problem
Poorly soluble drugs face challenges with low solubility and stability issues, leading to reduced therapeutic efficacy and side effects, as well as difficulties in accurate dosing and application due to their viscosity characteristics, particularly in pharmaceutical and cosmetic formulations.
Innovation Solution
A sol-gel composition comprising microcrystalline cellulose/carboxymethylcellulose sodium, hydroxypropyl methylcellulose or polyvinylpyrrolidone vinyl acetate, and Poloxamer or Polysorbate, which undergoes reversible sol-gel transition in response to physical force at isothermal temperatures, enhancing solubility and stability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If poorly soluble drugs are used in pharmaceutical formulations, then therapeutic efficacy is reduced due to low solubility, but increasing solubility may lead to blood clots when applied as injection
Solution Approach 1:
The patent changes the physical state parameter of the drug formulation by using sol-gel transition. The drug is formulated in a gel state at storage temperature with controlled viscosity to maintain solubility and stability, then transitions to a liquid state at application temperature for safe administration, avoiding blood clots while maintaining therapeutic efficacy
Solution Approach 2:
The patent utilizes sol-gel phase transition of the formulation. The composition exists as a gel phase during storage to prevent sedimentation and maintain drug solubility, then transitions to sol phase upon application to ensure safe injection without blood clot formation, resolving the contradiction between efficacy and safety
2Stability of the object's composition
If suspension formulations are used, then stability is improved by preventing sedimentation through high viscosity, but metering and oral administration become difficult due to low flowability
Solution Approach 1:
The patent applies dynamic viscosity control through sol-gel transition. The formulation maintains high viscosity in gel state during storage for stability, then transitions to low viscosity sol state during metering and administration for ease of operation. This dynamic property change resolves the contradiction between stability and ease of use
Solution Approach 2:
The patent changes the viscosity parameter of the formulation by controlling sol-gel transition. During storage, the formulation is maintained in gel state with high viscosity to prevent sedimentation. During administration, temperature or mechanical stimulation triggers transition to sol state with low viscosity, enabling easy metering and flow, thus resolving the contradiction
3Ease of operation
If syrup formulations are used with low viscosity, then ease of metering is improved, but spillage occurs during metering and oral administration
Solution Approach 1:
The patent uses dynamic viscosity adjustment through sol-gel transition. During metering, the formulation is in sol state with low viscosity for ease of flow and metering. During storage and application, it transitions to gel state with high viscosity to prevent spillage, resolving the contradiction between metering ease and spillage prevention
4Ease of operation
If cosmetics are designed to maintain flowability during application, then ease of application is improved, but stability is reduced due to constant fluid state
Solution Approach 1:
The patent applies sol-gel phase transition to cosmetic formulations. The product is stored in gel state for stability, then transitions to sol state upon application through friction or temperature change, providing ease of application. After application, it returns to gel state to maintain stability on the skin, resolving the contradiction between application ease and stability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition prevents sedimentation during storage, facilitates easy measurement and application, and improves the delivery of poorly soluble drugs by adjusting viscosity, ensuring stability and effective delivery of drugs or cosmetics.
Implementation Method 1
a sol-gel composition enabling reversible sol-gel transition and, more specifically, to a sol-gel composition of which the viscosity changes by physical force applied from the outside so that reversible sol-gel transition is performed
Implementation Method 2
it has low flowability, but changes into a fluid with high flowability as friction is applied during application... the composition exhibits a high viscosity in the form of a gel to prevent sedimentation of particles during storage
Data Source
AI summary
One aspect of the present disclosure relates to a sol-gel composition enabling reversible sol-gel transition and, more specifically, to a sol-gel composition of which the viscosity changes by external physical force so that reversible sol-gel transition is performed.