Solanum Extract Photoprotection Against Oxidative Stress
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Solution Overview
Problem
Current treatments for inflammation and cutaneous photodamage are inadequate in preventing chronic inflammation and skin damage caused by excessive reactive oxygen species and free radicals, often leading to oxidative stress and premature skin aging.
Innovation Solution
A pharmaceutical and cosmetic composition containing a water-soluble extract from the Solanum genus, specifically comprising solamargine and solasonine, which is extracted using an acidic aqueous solution and further processed to form a chloroform-alcohol mixture, resulting in a photoprotective agent that can be administered topically or orally.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional treatments for inflammation and photodamage are used, then some symptomatic relief may be achieved, but they fail to prevent chronic inflammation and oxidative stress caused by excessive reactive oxygen species and free radicals
Solution Approach 1:
The patent applies antioxidant compounds (solamargine and solasonine from Solanum genus) that convert the harmful effect of reactive oxygen species into a beneficial outcome by neutralizing these free radicals. The composition transforms the oxidative stress pathway into a protective mechanism, reducing chronic inflammation and photodamage while utilizing the body's natural antioxidant defense systems.
Solution Approach 2:
The patent employs preventive action by applying the pharmaceutical composition before oxidative damage and chronic inflammation fully develop. The composition proactively reduces reactive oxygen species accumulation and prevents the cascade of inflammatory responses, addressing the root cause before pathological changes become irreversible.
2Reliability
If high concentrations of antioxidant compounds are used to reduce oxidative stress, then photoprotection improves, but the complexity of the composition and manufacturing process increases
Solution Approach 1:
The patent utilizes a composite pharmaceutical composition containing multiple active compounds (solamargine and solasonine) extracted from the Solanum genus plant. This composite approach combines synergistic antioxidant components that work together to enhance photoprotection while maintaining a natural source-based formulation that simplifies manufacturing compared to synthesizing multiple separate antioxidant agents.
Solution Approach 2:
The patent extracts the active photoprotective compounds (solamargine and solasonine) directly from the Solanum genus plant through natural extraction processes. This extraction method simplifies the composition formulation by obtaining a concentrated source of multiple active antioxidants in their natural synergistic combination, avoiding the need to separately formulate and combine multiple synthetic antioxidant compounds.
3Reliability
If multiple phytochemicals are combined to enhance antioxidant effects, then the therapeutic benefit increases, but the manufacturing precision and quality control become more difficult
Solution Approach 1:
The patent employs a multi-functional pharmaceutical composition where the Solanum genus extract provides multiple simultaneous benefits: antioxidant activity, anti-inflammatory effects, and photoprotection. This single extracted source delivers a spectrum of active compounds that work synergistically, simplifying quality control compared to managing multiple separate phytochemical formulations while maintaining comprehensive therapeutic effects.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively inhibits inflammatory responses, reduces oxidative stress, and alleviates skin damage by decreasing the expression of NF-kB, COX-2, and iNOS, while improving skin elasticity and moisture retention, thus preventing and treating cutaneous photodamage.
Implementation Method 1
oxidative stress forms when ROS and free radicals exceed the antioxidant capacity provided by the interacting network of the cells or tissues
Implementation Method 2
subjecting a plant material of a plant of Solanum genus to an extraction treatment using an acidic aqueous solution with a pH value of 3∼5
Implementation Method 3
admixing the dried product obtained in step (c) with chloroform, followed by addition of a suitable amount of a 100% alcohol, such that a chloroform-alcohol mixture is formed
Data Source
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AI summary
The present invention relates to a pharmaceutical composition for preventing and treating inflammation and cutaneous photodamage, which contains a water-soluble extract from a plant of Solanum genus. The composition also has a photoprotective effect, and can be used as a cosmetic composition.