Solid Lipid Oil-in-Water Emulsion for Sustained Arthropod Control

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Solution Overview

Problem

Conventional oil-in-water emulsions with arthropod repellent active ingredients have limited long-term efficacy due to high vapor pressure, leading to rapid evaporation and short-term protection against pests.

Innovation Solution

An oil-in-water emulsion comprising a solid lipid material combined with a liquid oil-soluble active ingredient, where the active ingredient has a Log P greater than 0.5, is dispersed in a continuous aqueous phase with a stabilizer, and the emulsion is prepared by heating above the solid lipid's melting point and then cooling below it, creating a stable matrix for prolonged release.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Illumination intensity

If high vapor pressure active ingredients are used for spatial repellency, then arthropod detection distance is improved, but duration of protection deteriorates due to rapid evaporation

Engineering Contradiction:
Improvegas phase concentrationVSAvoidprotection duration
Core Design Contradiction:
Illumination intensityVSDuration of action of moving object

Solution Approach 1:

The patent changes the physical state of the lipid material from liquid to solid form. This parameter change fundamentally alters the release kinetics of the active ingredient, transforming rapid evaporation into controlled, sustained release while maintaining adequate vapor pressure for arthropod detection

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The invention creates a composite system combining solid lipid material with liquid oil-soluble active ingredient. This composite structure allows the solid lipid matrix to control the release rate of the volatile active ingredient, simultaneously achieving spatial repellency and prolonged protection

Inventive Principle:
Principle #40Composite materials

2Illumination intensity

If liquid oil-soluble active ingredients are used in conventional emulsions, then spatial repellency is achieved, but long-term efficacy deteriorates due to rapid evaporation

Engineering Contradiction:
Improvevapor pressureVSAvoidlong-term efficacy
Core Design Contradiction:
Illumination intensityVSReliability

Solution Approach 1:

The patent changes the physical state of the lipid carrier from liquid to solid. This parameter change creates a matrix that retains the volatile active ingredient while allowing controlled release, thereby maintaining vapor pressure for spatial repellency while achieving long-term efficacy

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The solid lipid material acts as an intermediary between the volatile active ingredient and the environment. It mediates the release process, allowing the active ingredient to maintain adequate vapor pressure for detection while preventing rapid evaporation through the solid matrix structure

Inventive Principle:
Principle #24Intermediary (Mediator)

3Duration of action of moving object

If solid lipid material is used to prolong release, then duration of action is improved, but manufacturing complexity increases due to temperature control requirements

Engineering Contradiction:
Improverelease durationVSAvoidprocess complexity
Core Design Contradiction:
Duration of action of moving objectVSDevice complexity

Solution Approach 1:

The patent utilizes the phase transition of lipid material from solid to liquid during processing, and back to solid during cooling. This phase transition enables simple temperature-controlled mixing and emulsification processes that achieve prolonged release without complex manufacturing equipment

Inventive Principle:
Principle #36Phase transitions

Solution Approach 2:

The invention uses temperature as a controllable parameter to manage the solid-liquid transition of the lipid material. By controlling temperature during manufacturing, the process achieves prolonged release characteristics while maintaining manufacturing simplicity through standard heating and cooling procedures

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The emulsion provides a long-lasting arthropod control activity, reducing mosquito landings by up to 95% over 6 hours compared to pure active repellents in ethanol, offering sustained protection without the need for frequent reapplication.

Implementation Method 1

Dispersing an oil phase comprising at least one solid lipid material and at least one liquid oil-soluble active ingredient into a continuous aqueous phase comprising a stabilizer to obtain an oil-in-water emulsion, at a temperature above the melting point of the solid lipid material

Methodology Applied
Scientific EffectMelting: Melting

Implementation Method 2

Cooling the emulsion thus obtained to a temperature below the melting point of the solid lipid material

Methodology Applied
Scientific EffectFreezing: Freezing

Data Source

PatentUS20230095618A1Oil-in-water emulsion comprising a solid lipid material
Publication Date: 2023.03.30 FIRMENICH SA
  • US20230095618A1 patent drawing
  • US20230095618A1 patent drawing

AI summary

The present invention relates to the field of delivery systems. More specifically, the invention concerns an oil-in-water emulsion comprising a solid lipid material in combination with a liquid oil-soluble active material, preferably an arthropod control agent. The present invention also describes a process for preparing said emulsion and consumer products comprising said emulsion.