Solid Lipid Composition for High-Loading Bioactive Oil Encapsulation
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Liquid oils, particularly those with bioactive components like fish oils, face challenges such as chemical instability, oxidative deterioration, unpleasant taste and odor, and non-uniform dosing, which affect their handling, storage, and efficacy in pharmaceutical and nutraceutical products.
Innovation Solution
Converting liquid oils into solid forms using lipid components that are mixed and processed to create a stable, free-flowing solid composition, allowing for high oil loadings without clumping, and enhancing storage stability and uniformity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If liquid oils are used in pharmaceutical and nutraceutical products, then the products can contain bioactive components, but the oils exhibit chemical instability and oxidative deterioration
Solution Approach 1:
The patent applies phase transition by converting liquid oils into solid forms through freezing and lyophilization processes. The oil is frozen at low temperatures and then lyophilized to produce a solid composition that maintains the bioactive components while eliminating the chemical instability and oxidative deterioration associated with liquid state oils.
Solution Approach 2:
The patent changes physical parameters by transforming the oil from liquid to solid state through controlled freezing and lyophilization. This parameter change from liquid to solid phase fundamentally alters the chemical stability and storage characteristics of the oil, preventing oxidative deterioration while preserving bioactivity.
2Reliability
If liquid oils are used in products, then bioactive components can be included, but the oils have unpleasant taste and odor that reduce consumer compliance
Solution Approach 1:
The patent uses phase transition from liquid to solid form to mask the unpleasant taste and odor of liquid oils. The solidified oil composition, produced through freezing and lyophilization, presents a different sensory profile that is more acceptable to consumers while maintaining the same bioactive components.
Solution Approach 2:
The patent introduces an intermediary process (freezing and lyophilization) that transforms the oil into a solid composition. This intermediary transformation acts as a mediator between the problematic liquid oil and the final consumer product, eliminating unpleasant sensory characteristics while preserving therapeutic benefits.
3Reliability
If liquid oils are used in dosing applications, then bioactive delivery is possible, but the dosing is non-uniform which affects efficacy
Solution Approach 1:
The patent applies phase transition to convert liquid oil into a solid composition with uniform physical properties. The freezing and lyophilization process creates a solid matrix where the oil is distributed uniformly, enabling precise and consistent dosing in pharmaceutical and nutraceutical applications.
Solution Approach 2:
The patent changes the physical state parameter from liquid to solid, which fundamentally improves dosing uniformity. The solid composition allows for precise measurement and consistent delivery of bioactive components, eliminating the non-uniform dosing problems associated with liquid oils.
4Ease of manufacture
If spray drying is used to encapsulate oils, then the oils can be processed, but the process requires aqueous feed and yields large particles with low oil payloads
Solution Approach 1:
The patent uses freezing and lyophilization instead of spray drying to avoid the limitations of aqueous processing. This phase transition approach allows for high oil payloads in the final solid composition without requiring the oil to be dissolved in water, thereby maximizing the quantity of oil that can be incorporated.
Solution Approach 2:
The patent replaces the spray drying mechanical system with a freezing and lyophilization system. This substitution eliminates the requirement for aqueous feed and the production of large particles with low oil payloads, allowing for high-concentration oil formulations.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solid compositions improve handling, storage stability, and uniformity of bioactive oils, masking unpleasant tastes and odors, and maintaining the stability and bioactivity of key components like omega-3 fatty acids, making them suitable for various applications including pharmaceuticals and nutraceuticals.
Implementation Method 1
converting liquid oils into solid forms using lipid components that are mixed and processed to create a stable, free-flowing solid composition
Implementation Method 2
maintaining the stability and bioactivity of key components like omega-3 fatty acids
Implementation Method 3
lipid components that are mixed and processed to create a stable, free-flowing solid composition
Implementation Method 4
Converting liquid oils into solid forms using lipid components that are mixed and processed
Data Source
AI summary
The present invention relates to a solid composition which contains a mixture of liquid oil and solid lipid. The solid lipid acts as a solid carrier vehicle for the oil thereby permitting oils to be provided, at relatively high loading, in solid form.