Solid Nicotine Salts and Co-crystals for Handling Stability

The patent transforms nicotine from liquid oil form to solid salt form by changing its chemical state through salt formation with various acids. This parameter change from liquid to solid phase resolves the handling difficulty while maintaining high nicotine concentration, as solid nicotine salts are easier to store, measure, and incorporate into products compared to viscous nicotine oil.

The patent creates composite nicotine salt materials by combining nicotine with various acids (benzoic acid, orotic acid, salicylic acid, etc.) to form new compounds with desirable properties. These composite nicotine salts combine the high nicotine content requirement with improved physical properties including solid state, enhanced stability, and better handling characteristics compared to pure nicotine oil.

The patent converts the potential harm of nicotine degradation into a benefit by selecting acids that guide degradation toward non-toxic pathways. Conventional nicotine salts degrade into harmful substances, but the patent's selected acids (orotic acid, salicylic acid, benzoic acid) structurally guide degradation to produce benign compounds, thus converting the harmful degradation process into a safe one while maintaining nicotine delivery effectiveness.

The patent creates composite nicotine salt materials with specifically selected acids that modify the degradation pathway. These composite salts are engineered to degrade into non-toxic products rather than harmful substances, resolving the issue of toxic degradation while preserving nicotine delivery. The molecular structure of the composite salts determines the safe degradation outcome.