Solid Nutritional Composition Stability via Buffering Salt and Choline Bitartrate
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Solution Overview
Problem
Existing solid compositions containing uridine, polyunsaturated fatty acids, and choline sources face stability issues during manufacturing, particularly with choline chloride's hygroscopicity and protein instability when combined with milk proteins, leading to phase separation, clumping, and poor reconstitution in powder forms.
Innovation Solution
A solid composition in powder form incorporating uridine, omega-3 fatty acids, choline bitartrate, a buffering salt component, and a milk protein source, specifically using skim milk powder and a buffering salt with a pH range of 5-8, to overcome stability issues and provide a stable, easy-to-reconstitute product.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Shape
If choline chloride is used as the choline source in solid composition, then the composition can be formulated as a solid powder, but the composition exhibits hygroscopicity and poor stability during manufacturing and storage
Solution Approach 1:
The patent changes the chemical form of choline from chloride to bitartrate salt, which fundamentally alters the hygroscopic properties and stability characteristics of the choline component in the solid composition
Solution Approach 2:
The patent creates a composite powder formulation combining choline bitartrate with milk proteins and buffering salts, where the interaction between components provides stability that individual components cannot achieve alone
2Quantity of substance
If milk proteins are combined with choline bitartrate in solid composition, then the composition provides complete nutritional profile, but the composition exhibits protein instability, phase separation, clumping, and poor reconstitution
Solution Approach 1:
The patent adjusts the pH parameter by incorporating buffering salt components that maintain pH between 5-8, which optimizes protein stability and prevents phase separation and clumping in the solid composition
Solution Approach 2:
The buffering salt acts as an intermediary component that mediates between choline bitartrate and milk proteins, preventing direct unfavorable interactions and maintaining overall composition stability
3Reliability
If liquid formulation is used for brain health supplement, then the composition provides good bioavailability, but the composition has high transport costs and inconvenient storage and distribution
Solution Approach 1:
The patent transitions the composition from liquid phase to solid powder phase through lyophilization or spray drying, enabling convenient storage and transport while maintaining the bioavailability of active ingredients upon reconstitution
Data Source
AI summary
The invention pertains to a solid composition suitable for treating adult animals that suffer from brain-related disorders, brain-related decline or brain-related diseases, preferably suitable for treating adult animals that suffer from brain-related disorders, the composition containing (i) a uridine source, wherein the amount of the sum of all uridine sources, calculated on the basis of the weight of the molar equivalent of uridine monophosphate (UMP), is 0.3-15 g per 100 g dry weight of the composition, (ii) a polyunsaturated fatty acid, preferably an omega-3 polyunsaturated fatty acid, (iii) choline bitartrate, (iv) a buffering salt component, and (v) a milk protein source, wherein the milk protein source is a milk powder, and the buffering salt component containing at least one food approved salt, with a buffering capacity between pH 5-8, the buffering salt component preferably containing a mixture of food-approved salts, or a food-approved salt and its conjugated acid or base.