Solid Colonic Purgative Composition for Taste-Masked Cleansing

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Solution Overview

Problem

Existing colonic purgatives face challenges with poor compliance due to high dosage, unpleasant taste, and the need for excessive water intake, leading to incomplete colon cleansing and reduced screening rates for procedures like colonoscopy.

Innovation Solution

A colonic purgative composition comprising sodium picosulfate, potassium sulfate, and magnesium sulfate, optionally with simethicone, formulated as a solid preparation with a reduced dosage and improved taste masking, utilizing a combination of water-soluble binders and lubricants to enhance medication compliance and efficacy.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If a high dosage of purgative is used to ensure complete colon cleansing, then the colon cleanliness is improved, but the patient compliance deteriorates due to unpleasant taste and odor

Engineering Contradiction:

Improvecolon cleanlinessVSAvoidpatient compliance

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent introduces taste-masking agents and odor-reducing agents as intermediary substances that mediate between the purgative active ingredients and the patient's sensory perception. These intermediaries mask the unpleasant taste and reduce the characteristic odor without affecting the purgative efficacy, thereby resolving the contradiction between maintaining colon cleanliness and improving patient compliance.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent formulates a composite preparation containing multiple components including purgative active ingredients, taste-masking agents, odor-reducing agents, and excipients. This composite formulation integrates multiple functions within a single preparation, achieving both effective colon cleansing and improved sensory acceptance through the synergistic combination of components.

Inventive Principle:

Principle #40Composite materials

2Ease of operation

If the dosage of purgative is reduced to improve patient compliance, then the medication adherence is improved, but the colon cleansing efficacy deteriorates

Engineering Contradiction:

Improvemedication adherenceVSAvoidcolon cleansing efficacy

Core Design Contradiction:

Ease of operationVSReliability

Solution Approach 1:

The patent optimizes the dosage parameters of the purgative active ingredients within a specific range (sodium picosulfate 5-15 mg, magnesium sulfate 3-9 g, potassium sulfate 2-6 g per day) to achieve the threshold effect necessary for colon cleansing. By precisely controlling these parameters and combining them with taste-masking and odor-reducing agents, the patent maintains adequate cleansing efficacy while improving medication adherence.

Inventive Principle:

Principle #35Parameter changes

3Ease of manufacture

If a liquid formulation is used to ensure proper mixing and dissolution, then the preparation ease is improved, but the distribution cost and stability deteriorate

Engineering Contradiction:

Improvepreparation easeVSAvoiddistribution cost

Core Design Contradiction:

Ease of manufactureVSQuantity of substance

Solution Approach 1:

The patent transitions the formulation from liquid to solid phase (tablet or capsule form). This phase transition enables the purgative to be manufactured in a stable, space-efficient form that reduces distribution costs and storage requirements while maintaining ease of preparation through simple dissolution in water before administration.

Inventive Principle:

Principle #36Phase transitions

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition provides excellent colon cleansing while significantly improving medication compliance by reducing the dosage and minimizing the unpleasant taste and odor, ensuring effective preparation for procedures like colonoscopy.

Implementation Method 1

Osmotic purgatives are non-absorbable electrolyte solutions that create a difference in osmotic pressure in the intestine after ingestion to wash out feces

Methodology Applied

Scientific EffectOsmotic pressure: Osmotic Pressure

Implementation Method 2

Stimulant purgatives interfere with the absorption of water and electrolytes in the large intestine and stimulate the intestinal mucosa to induce contraction of the colon muscles to force defecation

Methodology Applied

Scientific EffectStimulatory effect on intestinal mucosa:

Data Source

PatentUS20250302871A1Colonic purgative composition

Publication Date: 2025.10.02 VIVOZON INC

AI summary

The present invention relates to a colonic purgative composition and a preparation method therefor, and more specifically, to a colonic purgative composition comprising sodium picosulfate, potassium sulfate and magnesium sulfate, and a preparation method therefor.