Solid R-Beta-Hydroxybutyric Acid for Salt-Free Ketosis Delivery
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Solution Overview
Problem
Current administration methods for beta-hydroxybutyrate, such as salts and polymers, face issues with excessive intake leading to health problems and slow delivery, respectively.
Innovation Solution
Administering pharmaceutically effective amounts of R-beta-hydroxybutyrate, potentially combined with other compounds, to induce and maintain ketosis, promote weight loss, and improve health outcomes, while minimizing side effects and optimizing delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If beta-hydroxybutyrate salts are administered to promote weight loss and ketosis, then weight loss and ketosis are achieved, but excessive salt intake causes health problems such as high blood pressure, stroke, and organ damage
Solution Approach 1:
The patent extracts the active ingredient beta-hydroxybutyrate from its traditional salt form and administers it as a free acid or in non-salt formulations. This separates the therapeutic effect (ketosis induction and weight loss) from the harmful component (excessive salt intake), allowing effective dosing without the associated health risks of hypertension, stroke, and organ damage
Solution Approach 2:
The patent changes the chemical form parameter of beta-hydroxybutyrate from salt form to free acid form or alternative delivery systems. This parameter change maintains the pharmacological activity while eliminating the harmful electrolyte load, enabling safe administration at effective doses for ketosis and weight loss
2Reliability
If polymers of beta-hydroxybutyrate are administered to promote ketosis, then ketosis is achieved, but delivery is slow and larger amounts must be administered
Solution Approach 1:
The patent extracts beta-hydroxybutyrate from polymer form and administers it in smaller, more readily absorbed molecular forms such as free acid or salt-free formulations. This extraction from polymer structure enables faster absorption and delivery to target tissues while maintaining reliable ketosis induction at lower doses
Solution Approach 2:
The patent changes the molecular size and solubility parameters of beta-hydroxybutyrate by administering it as free acid or alternative formulations rather than polymers. This parameter change accelerates dissolution and absorption rates, improving delivery speed while maintaining the reliability of ketosis induction
Data Source
AI summary
Beta-hydroxybutyric acid compositions in the form of a powder or other solid formulated for ingestion by oral delivery by mixing with water or other aqueous liquid to form a beverage that includes a liquid carrier, such as water, milk, drinkable liquid, coconut water, watermelon water, or electrolyte water, and beta-hydroxybutyrate, wherein the beta-hydroxybutyrate can be enriched in R-beta-hydroxybutyrate relative to S-beta-hydroxybutyrate, wherein the beta-hydroxybutyrate comprises R-beta-hydroxybutyric acid, S-beta-hydroxybutyric acid, and optionally one or more salts or esters of R-beta-hydroxybutyrate and one or more salts or esters S-beta-hydroxybutyrate.