Solid Solution Lipid Compositions for Cardiovascular Treatment
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Solution Overview
Problem
Current treatments for cardiovascular diseases associated with high lipid and/or lipoprotein levels are inadequate, as existing therapies like statins and fibrates have limitations such as not reducing triglyceride levels effectively and causing significant side effects when used in combination.
Innovation Solution
Development of solid solution pharmaceutical compositions that incorporate therapeutic compounds with room temperature solid and liquid lipids, stabilizing agents, and neutralizing agents to create a lipid-adjuvant delivery system that effectively modulates lipid and lipoprotein levels, targeting macrophages and dendritic cells for improved cardiovascular disease treatment.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing therapies like statins and fibrates are used to treat cardiovascular diseases, then lipid and lipoprotein levels are modulated, but they have limitations such as not reducing triglyceride levels effectively and causing significant side effects when used in combination
Solution Approach 1:
The patent employs a composite lipid formulation comprising multiple lipid types (triglycerides, phospholipids, cholesterol, and fatty acids) in specific ratios to create a therapeutic composition that simultaneously addresses multiple lipid abnormalities including triglycerides, cholesterol, and lipoprotein levels, thereby achieving broader treatment efficacy with a single agent rather than requiring combination therapy with statins and fibrates
2Reliability
If combination therapy with statins and fibrates is used to treat cardiovascular diseases, then lipid and lipoprotein levels are reduced, but significant side effects occur
Solution Approach 1:
The patent merges multiple therapeutic functions into a single lipid-based formulation that can simultaneously lower triglycerides, cholesterol, and lipoprotein levels through one administration, eliminating the need for combination therapy with multiple drugs and thereby avoiding the side effects associated with polypharmacy while maintaining comprehensive treatment efficacy
Data Source
AI summary
The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.