Solid Staining Tablets for Histology
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Solution Overview
Problem
Current staining solutions for histological and cytological samples are bulky, flammable, and unstable, requiring specialized storage and transportation, and can degrade during long storage or transport, leading to inaccurate results.
Innovation Solution
Development of solid or semi-solid compositions containing staining substances like hematoxylin, eosin, OG6, and Light Green, along with additives and excipients, which can be easily mixed with solvents to create ready-to-use staining solutions in single-dose sachets or tablets, eliminating the need for large, flammable liquid solutions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If liquid staining solutions are used, then staining capability is achieved, but storage and transportation become complex due to flammability and bulk requirements
Solution Approach 1:
The patent changes the physical state of the staining solution from liquid to solid form by using staining tablets or capsules containing powdered or crystalline staining compounds. This parameter change eliminates flammability concerns, reduces packaging volume, and simplifies storage and transportation while maintaining staining capability when the tablets are dissolved in appropriate solvents before use
Solution Approach 2:
The patent employs single-use staining tablets or capsules that are disposed of after one use. This eliminates the need for long-term storage of large quantities of liquid staining solutions, reduces packaging requirements, and avoids the complexities associated with storing flammable liquids, while still providing reliable staining functionality
2Reliability
If large quantities of staining solutions are stored, then continuous availability is ensured, but transportation and storage costs increase
Solution Approach 1:
The patent divides the staining solution into individual single-dose tablets or capsules. This segmentation allows laboratories to store only the small quantity of tablets needed for immediate use rather than maintaining large volumes of liquid staining solutions, thereby reducing storage space and transportation costs while ensuring continuous availability through simple restocking of compact tablet packages
3Loss of time
If staining solutions are prepared in advance, then time efficiency is improved, but stability and accuracy deteriorate during storage
Solution Approach 1:
The patent performs preliminary preparation by pre-formulating stable solid staining tablets or capsules that can be stored indefinitely without degradation. When needed, these pre-prepared tablets are quickly dissolved in solvents to create fresh staining solutions, thus maintaining both time efficiency (quick preparation) and reliability (accurate staining results) without the problems associated with storing liquid staining solutions
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
These compositions ensure freshly prepared staining solutions with improved stability and safety, reducing transportation and storage costs, environmental impact, and the risk of inaccurate results, while providing efficient and reproducible staining capabilities.
Implementation Method 1
The metal-hematin complexes are those that are found to permanently stain cell nuclei
Implementation Method 2
eosin binding instead to the plasma-proteins that have positive charge
Data Source
AI summary
The present invention relates to compositions for the preparation of solutions for contrast staining of biological, cytological, histological and autopsical samples, and their use in the preparation of said samples to be analysed.