Solid Veterinary Dosage Form Using Spray-Drying and Milling
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Solution Overview
Problem
Existing veterinary pharmaceutical formulations for drinking water medication face challenges such as sedimentation, stability issues, and inefficiencies due to low water solubility of antimicrobials and antiparasitic drugs, leading to ineffective dosing and potential resistance development.
Innovation Solution
Development of spray-dried solid pharmaceutical multiparticulate dosage forms comprising a non-ionic surfactant with an HLB of at least 8 and maltodextrin with a DE of at least 10, which are milled to reduce particle size and then spray-dried to create a stable, easily dispersible powder that remains stable in drinking water.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If liquid formulations are used to improve water solubility of drugs, then solubility is improved, but transportation efficiency decreases due to large amounts of liquid and non-active ingredients
Solution Approach 1:
The patent transitions the drug formulation from liquid phase to solid phase by spray-drying the suspension to create a powder or granule. This solid formulation maintains the solubility benefits of the liquid suspension during storage but eliminates the transportation inefficiency of large liquid volumes, as only the dry powder needs to be transported and can be redispersed in water at the point of use
2Stability of the object's composition
If solid formulations are used to improve stability and reduce transportation volume, then stability is improved, but sedimentation occurs after a certain period in drinking water
Solution Approach 1:
The patent performs preliminary milling of the suspension before spray-drying to reduce particle size to the low micrometer range. This pre-treatment ensures that when the solid formulation is later redispersed in drinking water, the fine particles remain suspended effectively for a prolonged period without settling, thus maintaining reliability while preserving stability
Solution Approach 2:
The patent changes the physical parameters of the formulation by controlling particle size through milling and using spray-drying to create a specific powder morphology. These parameter changes optimize both the stability during storage and the suspending ability in water, resolving the contradiction between the two properties
3Ease of manufacture
If conventional spray-drying is used without proper suspension preparation, then production is simplified, but particle size increases leading to sedimentation
Solution Approach 1:
The patent applies preliminary milling to the suspension before spray-drying to pre-reduce particle size. This preliminary action ensures that even with a simple spray-drying process, the final particles are fine enough to prevent sedimentation, thus maintaining manufacturing precision without complicating the production process
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution provides a stable and efficient delivery system that prevents sedimentation, maintains effective dosing for a longer period, and allows for use in proportioners, reducing the risk of resistance and improving animal health management.
Implementation Method 1
a non-ionic surfactant having an Hydrophilic Lipophilic Balance (HLB) of at least 8
Implementation Method 2
improve the wettability of the compound
Implementation Method 3
spray-drying said milled suspension
Implementation Method 4
milling said suspension
Data Source
AI summary
The present invention relates to solid pharmaceutical dosage forms suitable for use as drinking water medication. More in particular, the present invention provides solid pharmaceutical dosage forms comprising a pharmaceutically active agent, a non-ionic surfactant having an Hydrophilic Lipophilic Balance (HLB) of at least 8, and a maltodextrin. The present invention also provides the use of such pharmaceutical dosage forms in veterinary medicine, more in particular as drinking water medication; as well as methods for preparing such pharmaceutical dosage forms.