Soluble Matrix Capillary Filtration for Pressure Spike Elimination

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Solution Overview

Problem

Filtration systems, particularly in medical diagnostic applications, face challenges with transient pressure spikes when initially passing liquid through filters, which is difficult to manage in low-cost, handheld, disposable systems due to capillary forces associated with hydrophobic or hydrophilic filter materials.

Innovation Solution

Employing a soluble matrix with higher capillarity than the initial filter, which dissolves in the liquid, allowing capillary forces to draw the liquid out of the filter without additional pressure, and strategically placing a venting duct to exclude the soluble matrix from the collected filtrate, reducing interference in downstream processing.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If a hydrophobic filter material is used, then liquid flow resistance is reduced for steady state operation, but initial pressure spike increases due to capillary forces

Engineering Contradiction:
Improveliquid flow rateVSAvoidinitial pressure spike
Core Design Contradiction:
ProductivityVSStress or pressure

Solution Approach 1:

A surfactant is introduced as an intermediary substance that modifies the surface properties of the filter material. The surfactant reduces the contact angle between the liquid and the hydrophobic filter, thereby reducing capillary pressure and the initial pressure spike while maintaining the hydrophobic character for steady-state flow resistance

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The surface energy parameters of the filter material are changed by applying a surfactant treatment. This modifies the contact angle and surface tension characteristics, allowing the filter to transition from high capillary pressure state to lower capillary pressure state while maintaining its filtration performance

Inventive Principle:
Principle #35Parameter changes

2Stress or pressure

If a hydrophilic filter material is used, then initial pressure spike is reduced, but liquid flow resistance increases for steady state operation

Engineering Contradiction:
Improveinitial pressure spikeVSAvoidliquid flow rate
Core Design Contradiction:
Stress or pressureVSProductivity

Solution Approach 1:

The surface energy parameters of the filter material are precisely controlled to achieve an optimal balance. By adjusting the contact angle and surface tension characteristics, the filter maintains sufficient capillary action to reduce initial pressure spike while preserving adequate pore openness for steady-state flow rate

Inventive Principle:
Principle #35Parameter changes

3Manufacturing precision

If small pore size is used, then filtration precision is improved, but capillary forces increase causing higher pressure requirements

Engineering Contradiction:
Improvefiltration precisionVSAvoidpressure requirement
Core Design Contradiction:
Manufacturing precisionVSStress or pressure

Solution Approach 1:

A surfactant is introduced as a mediator that acts at the liquid-filter interface. It reduces the surface tension effects in small pores, thereby maintaining the fine filtration precision of small pore sizes while significantly reducing the capillary pressure that would otherwise require high operating pressures

Inventive Principle:
Principle #24Intermediary (Mediator)

4Productivity

If filter pore structure is optimized for flow, then productivity is improved, but capillary control capability is reduced

Engineering Contradiction:
Improveliquid flow rateVSAvoidcapillary control capability
Core Design Contradiction:
ProductivityVSReliability

Solution Approach 1:

The surfactant serves as a controllable intermediary that modulates capillary forces. It allows the filter pore structure to be optimized for high flow rates while the surfactant provides dynamic control over capillary pressure, ensuring reliable operation across different flow conditions

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This method eliminates the need for initial pressure spikes, enables efficient liquid extraction from filters without mechanical intervention, and ensures cleaner filtrates by managing capillary forces, making the process more efficient and cost-effective for medical diagnostics.

Implementation Method 1

a soluble matrix in physical contact with at least a portion of a downstream surface of the at least one filtration membrane, the soluble matrix possessing a capillary drawing force sufficient to draw filtrate through the at least one filtration membrane

Methodology Applied
Scientific EffectCapillary forces: Capillary Action

Implementation Method 2

the soluble matrix possessing a capillary drawing force sufficient to draw filtrate through the at least one filtration membrane and into the soluble matrix, causing the soluble matrix to at least partially dissolve or disintegrate in the filtrate

Methodology Applied
Scientific EffectDissolution: Solvation

Implementation Method 3

at least one filtration membrane, and a soluble matrix in physical contact with at least a portion of a downstream surface of the at least one filtration membrane

Methodology Applied
Scientific EffectFiltration: Filter (physical)

Data Source

PatentUS11305236B2Surface tension driven filtration
Publication Date: 2022.04.19 GATTACO INC
  • US11305236B2 patent drawing
  • US11305236B2 patent drawing
  • US11305236B2 patent drawing

AI summary

Disclosed is a device for extracting a filtrate from a liquid sample that includes one or more filtration membranes and, in physical contact with a portion of the downstream surface(s) of the filtration membrane(s), a soluble matrix possessing a capillary drawing force sufficient to draw filtrate through the at least one filtration membrane and into the soluble matrix, causing the soluble matrix to at least partially dissolve or disintegrate in the filtrate, whereby the filtrate is released. Various configurations, including device configurations having two filtration membranes with a soluble matrix in between or having a tubular filtration membrane at least partially surrounding or surrounded by a soluble matrix are described.