Solventless Silicone Coating for Prefilled Syringe Sliding
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Prefilled syringes face challenges in maintaining stable liquid medicine discharge under high pressure and accuracy over time, with existing solutions either compromising on liquid-tightness and sliding performance or using hazardous organic tin compounds as catalysts.
Innovation Solution
A medical appliance with a slidable coating layer formed from a solventless-type hardening silicone-based resin, eliminating the need for organic tin compounds and ensuring stable sliding performance without lubricants, which prevents sticking and allows for smooth initial motion during use.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If silicone oil or lubricant is applied to the sliding portion to enhance sliding performance, then sliding performance is improved, but the liquid medicine deteriorates due to interaction with the lubricant during long-term storage
Solution Approach 1:
The invention extracts and removes the harmful lubricant (silicone oil) from the system entirely. Instead of applying lubricant to the sliding portion, the gasket is designed with a fluorine resin coating layer that provides low friction properties inherently, eliminating the need for separate lubricant application and preventing interaction between lubricant and liquid medicine during storage
Solution Approach 2:
The invention uses a composite structure consisting of a gasket body made of elastic body material and a coating layer made of fluorine resin. This composite material combination provides both the elasticity needed for sealing and the low friction properties needed for smooth sliding, without requiring additional lubricants that could interact with the liquid medicine
2Reliability
If fluorine resin coating layer is applied to eliminate lubricant use, then liquid medicine stability is improved, but sliding performance under high pressure and at low speeds deteriorates
Solution Approach 1:
The invention optimizes the parameters of the fluorine resin coating layer, specifically controlling the thickness to 1-30 μm and selecting appropriate fluorine resin materials with specific friction coefficients. These parameter adjustments ensure the coating provides sufficient sliding performance even under high pressure and low speed conditions while maintaining liquid medicine stability
Solution Approach 2:
The invention applies the fluorine resin coating layer selectively to specific portions of the gasket where sliding contact occurs, rather than coating the entire gasket. This localized application ensures low friction properties are concentrated where needed for sliding performance while maintaining the elastic body's sealing properties in other areas
3Ease of manufacture
If organic tin compound is used as catalyst for coating layer formation, then coating layer formation is improved, but harmful effects and environmental concerns are introduced
Solution Approach 1:
The invention replaces the harmful organic tin compound catalyst with a platinum-based catalyst or alternative catalytic system. This substitution eliminates the harmful effects and environmental concerns associated with organic tin compounds while maintaining or improving the coating layer formation process and resulting coating quality
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solventless coating layer provides favorable sliding properties at low speeds, prevents particle separation, and ensures consistent medication delivery without the risks associated with organic tin compounds, enhancing both the sliding and sealing performance of the syringe.
Implementation Method 1
a slidable coating layer which is formed of a composition containing a solventless-type hardening silicone-based resin
Data Source
Figure 1~2
Figure 3~4
Figure 5
AI summary
A medical appliance of the present invention having a slidable coating layer moves in contact with an inner surface of a medical member or that of a lumen. The medical appliance has the slidable coating layer formed at a part thereof which contacts the medical member or the lumen. The slidable coating layer is formed of a composition containing a solventless-type hardening silicone-based resin.