Sonorheometry Hemostatic Index Display for Quantitative Guidance

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Solution Overview

Problem

Current hemostasis detection methods are limited in providing a comprehensive representation of the hemostatic process, often requiring complex and expensive mechanical instruments that are difficult to operate and interpret, and do not provide timely or quantitative guidance for transfusion therapies, leading to suboptimal treatment of thrombotic and bleeding conditions.

Innovation Solution

A system for displaying multiple hemostatic indexes, including coagulation factor function, fibrinogen concentration, platelet function, and fibrinolytic function, using sonorheometry to quantify dynamic changes in whole blood coagulation and clot dissolution, with a graphical user interface (GUI) for intuitive interpretation and treatment recommendations.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If complex mechanical instruments are used for hemostasis detection, then measurement precision is improved, but device complexity increases and ease of operation deteriorates

Engineering Contradiction:

Improvehemostasis detection precisionVSAvoidinstrument operation difficulty

Core Design Contradiction:

Measurement precisionVSEase of operation

Solution Approach 1:

The patent replaces complex mechanical instruments with acoustic wave-based detection (sonorheometry). Ultrasound waves are transmitted through blood samples to measure mechanical properties such as clot formation and dissolution, eliminating the need for complex mechanical measurement devices while maintaining measurement precision.

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent transforms the measurement approach by changing physical parameters - using acoustic impedance and sound wave propagation characteristics to detect hemostatic parameters. This allows measurement of clot viscosity, elasticity, and other mechanical properties through acoustic signal analysis rather than mechanical measurement.

Inventive Principle:

Principle #35Parameter changes

2Loss of information

If comprehensive hemostatic parameters are measured, then information completeness is improved, but device complexity increases

Engineering Contradiction:

Improvehemostatic information completenessVSAvoiddetection system complexity

Core Design Contradiction:

Loss of informationVSDevice complexity

Solution Approach 1:

The patent creates a multi-functional detection system where a single sonorheometry device can measure multiple hemostatic parameters simultaneously including clot formation time, clot strength, fibrinogen levels, platelet function, and fibrinolytic activity. This universal approach eliminates the need for multiple separate complex instruments.

Inventive Principle:

Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent combines multiple hemostatic measurement capabilities into a single integrated system. By merging coagulation factor assessment, platelet function testing, and fibrinolytic evaluation into one sonorheometry platform, the system reduces device complexity while providing comprehensive hemostatic information.

Inventive Principle:

Principle #5Merging (Combining)

3Loss of information

If quantitative hemostatic assessment is performed, then treatment guidance quality is improved, but measurement precision requirements increase

Engineering Contradiction:

Improvetreatment guidance qualityVSAvoidquantitative measurement precision

Core Design Contradiction:

Loss of informationVSMeasurement precision

Solution Approach 1:

The patent implements feedback mechanisms where acoustic measurement data is processed to provide quantitative hemostatic indices that directly guide treatment decisions. The system compares measured parameters against reference ranges and provides actionable feedback for transfusion therapy management, improving treatment guidance quality.

Inventive Principle:

Principle #23Feedback

Solution Approach 2:

The patent transforms raw acoustic measurement data into clinically meaningful quantitative parameters through signal processing and mathematical modeling. By converting acoustic impedance changes into standardized hemostatic indices, the system achieves the required measurement precision for treatment guidance.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables healthcare professionals to quickly assess and respond to hemostatic conditions, providing timely and targeted treatment recommendations, reducing the need for empirical transfusions and optimizing the use of blood products.

Implementation Method 1

Methodology Applied

Scientific EffectSonorheometry:

Data Source

PatentUS12444498B2Hemostatic parameter display

Publication Date: 2025.10.14 HEMOSONICS LLC

AI summary

A system for displaying a plurality of hemostatic indexes is disclosed. The system includes a communication receiver configured to receive the hemostatic indexes and a graphical user interface (GUI) connected to the communication receiver and configured to simultaneously display the hemostatic indexes. The hemostatic indexes are derived from a plurality of independent measurements, such as the mechanical measurements determined using the sonorheometry systems and processes.