Sotalol Dosing System for Steady-State Concentration
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Solution Overview
Problem
Determining appropriate dosing of antiarrhythmic drugs for cardiovascular conditions is complex and time-consuming, requiring careful consideration of multiple parameters, which can be challenging in emergency situations where quick decision-making is necessary.
Innovation Solution
A computer-implemented method and system that prompts input for patient health characteristics and antiarrhythmic drug dosing history, determines the appropriateness of antiarrhythmic drugs, and outputs a dosing protocol for administering drugs like sotalol, dofetilide, amiodarone, ibutilide, dronedarone, procainamide, and propafenone, including IV loading doses and oral maintenance dosing intervals, to ensure safe and effective treatment.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If comprehensive dosing parameters are considered manually, then dosing accuracy and safety are improved, but decision-making time increases
Solution Approach 1:
The patent replaces manual mechanical calculation and decision-making processes with an automated computer system. The system automatically calculates dosing parameters based on input patient data, substituting the manual computational process with electronic computation to achieve both accuracy and speed.
Solution Approach 2:
The dosing system performs self-service by automatically generating dosing recommendations based on programmed criteria and patient inputs. The system independently processes the complex dosing calculations without requiring manual intervention, thereby reducing decision-making time while maintaining accuracy.
2Reliability
If multiple dosing parameters are considered simultaneously, then dosing safety is improved, but operational complexity increases
Solution Approach 1:
The patent segments the complex dosing decision process into distinct input parameters and processing steps. The system separates patient data input, dosing calculation, and recommendation generation into modular components, making the overall complex system more manageable and easier to implement.
Solution Approach 2:
The dosing system is designed with multi-functionality to handle various antiarrhythmic drugs and patient scenarios through a single unified platform. The system can process different dosing parameters for multiple drugs simultaneously, reducing operational complexity by consolidating multiple specialized systems into one universal solution.
3Productivity
If IV loading dose is administered, then steady-state concentration is achieved faster, but risk of concentration-dependent adverse effects increases
Solution Approach 1:
The patent implements feedback mechanisms where the system continuously monitors patient responses and adjusts dosing recommendations accordingly. The system uses feedback from patient data inputs and clinical parameters to modify dosing calculations, thereby reducing the risk of concentration-dependent adverse effects while maintaining rapid achievement of steady-state concentration.
Solution Approach 2:
The system dynamically changes dosing parameters based on patient-specific factors such as renal function, age, and weight. By adjusting parameters like loading dose amount and administration rate according to individual patient characteristics, the system achieves fast steady-state concentration while minimizing adverse effects risk through personalized parameter optimization.
Data Source
AI summary
The disclosure relates to a method which includes i) prompting input of: a creatinine clearance (CrCl) of a subject; whether the subject is being initiated or escalated on sotalol hydrochloride; an amount of an oral target dosage of sotalol hydrochloride for the subject; and optionally a projected start time for sotalol hydrochloride infusion; and ii) executing computer executable instructions to derive from a set of rules a sotalol hydrochloride dosing protocol for the subject based on the inputs. The disclosure also relates to systems and medical devices configured to perform one or more steps of the method, as well as a non-transitory computer-readable storage medium comprising computer-executable instructions or software stored thereon capable of performing one or more steps of the method.