Soy-Stabilized Gold Nanoparticles for Biocompatible Imaging
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Solution Overview
Problem
Current methods for producing gold nanoparticles for medical applications are often harsh and unsuitable for use with target-specific peptides, leading to reduced biospecificity and instability, making them ineffective for in vivo imaging and therapy.
Innovation Solution
Gold nanoparticles are stabilized using materials from the soy or lentil plant or their reactive extracts, eliminating the need for harsh chemicals and allowing for environmentally friendly production, enhancing biocompatibility and stability for medical applications.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If harsh chemicals like sodium borohydride are used to produce gold nanoparticles, then production efficiency is improved, but biospecificity and stability are reduced
Solution Approach 1:
The patent changes the chemical parameters of the synthesis process by using plant extracts (soy or lentil) instead of harsh chemicals like sodium borohydride. This parameter change maintains production efficiency while preserving the biosspecificity and stability of target-specific peptides, as the plant extracts provide a milder reducing environment that does not degrade peptide functionalities.
Solution Approach 2:
The patent introduces plant extracts as an intermediary substance that mediates the reduction of gold salts to nanoparticles. These extracts contain natural reducing agents that can reduce gold ions without the harsh effects of conventional chemicals, thereby maintaining both production efficiency and the integrity of biomolecules for stabilization.
2Stability of the object's composition
If thiols are used to stabilize gold nanoparticles, then stability against agglomeration is improved, but reactivity with drug moieties is reduced
Solution Approach 1:
The patent uses plant extract components (proteins, phenolics) as temporary stabilization agents during synthesis that can be subsequently replaced or work in conjunction with drug moieties. These natural stabilizers provide the necessary stability during production but do not permanently block the reactivity needed for therapeutic conjugation.
Solution Approach 2:
The patent creates a composite stabilization system where plant extract components work together with target-specific peptides and drug moieties. The plant proteins and phenolics provide steric and electrostatic stabilization against agglomeration, while leaving the functional groups on peptides and drugs available for their intended therapeutic functions.
3Ease of manufacture
If chemical cocktails are used during nanoparticle production, then production is simplified, but environmental friendliness and biocompatibility are reduced
Solution Approach 1:
The patent employs plant extracts that contain all necessary reducing and stabilizing components in a single natural material. The extract self-organizes to reduce gold ions and stabilize nanoparticles simultaneously, eliminating the need for multiple separate chemical reagents and simplifying the production process while being environmentally friendly and biocompatible.
Solution Approach 2:
The patent uses plant extracts as a universal reagent that performs multiple functions: reducing gold ions to nanoparticles, stabilizing the nanoparticles against agglomeration, and providing a biocompatible environment for therapeutic applications. This single material replaces multiple specialized chemicals, simplifying production while improving environmental and biological compatibility.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The resulting gold nanoparticles demonstrate high affinity for cancer cells, are biologically benign, and suitable for diagnostic imaging and therapy, including X-ray contrast and hyperthermia treatments, with enhanced stability and biocompatibility for in vivo use.
Implementation Method 1
an aqueous solution containing gold salts is mixed with soy or lentil plant based materials or reactive extracts thereof
Implementation Method 2
The nanoparticles are stabilized with material from soy or lentil plant material or extracted reactive extracts of soy or lentil material
Data Source
AI summary
The invention provides stabilized, biocompatible gold nanoparticles that are stabilized with material from soy or lentil plant material or a reactive extract thereof of the plant material. The gold nanoparticles of the invention can be fabricated with an environmentally friendly method for making biocompatible stabilized gold nanoparticles. The nanoparticles can be introduced in vivo to conduct enhanced imaging. The nanoparticles can also be introduced in vivo to conduct therapy.