Soybean Breeding for Herbicide Tolerance and Stable Trait Recovery

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Solution Overview

Problem

Existing soybean varieties lack improved combinations of traits such as higher seed yield, disease resistance, herbicide tolerance, and nutritional quality, making it challenging to develop stable and high-yielding soybean varieties that meet agronomic and commercial demands.

Innovation Solution

Development of the soybean variety 01106526, which incorporates genetic modifications and introgression of traits like glyphosate, glufosinate, and dicamba tolerance, along with improved agronomic characteristics, through a breeding program involving crosses, backcrossing, and genetic marker-assisted selection.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If conventional soybean breeding methods are used, then existing varieties maintain current trait combinations, but they lack improved combinations of traits such as higher seed yield, disease resistance, and herbicide tolerance

Engineering Contradiction:
Improvetrait combinationVSAvoidstable high-yielding variety
Core Design Contradiction:
Adaptability or versatilityVSReliability

Solution Approach 1:

The patent combines multiple desirable traits from different parental lines into a single soybean variety. Specifically, it merges disease resistance traits, herbicide tolerance traits, and high yield potential traits that were previously distributed across different varieties, creating a unified variety with superior comprehensive performance.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The breeding program systematically changes key parameters including seed yield, disease resistance levels, and herbicide tolerance thresholds. Through controlled crossing and selection, the variety achieves parameter improvements across multiple dimensions simultaneously, transforming the trait profile from conventional levels to enhanced levels.

Inventive Principle:
Principle #35Parameter changes

2Adaptability or versatility

If multiple traits are combined in a single variety, then agronomic quality and resistance improve, but the breeding program complexity increases

Engineering Contradiction:
Improveagronomic qualityVSAvoidbreeding program
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The breeding program is divided into distinct sequential phases: initial crossing to combine parental traits, backcrossing to recover recurrent parent background, and marker-assisted selection to fix target traits. Each phase has specific objectives and selection criteria, making the complex overall program manageable through segmentation into controllable steps.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

Molecular markers are used to provide feedback on the genetic composition of breeding lines at each stage. This allows breeders to monitor the presence of desired traits and the recovery of recurrent parent genome, enabling informed selection decisions and accelerating the breeding process while maintaining precision.

Inventive Principle:
Principle #23Feedback

3Adaptability or versatility

If genetic modifications are introduced for herbicide tolerance, then herbicide resistance improves, but the variety may lack stability in other characteristics

Engineering Contradiction:
Improveherbicide toleranceVSAvoidmorphological and physiological characteristics
Core Design Contradiction:
Adaptability or versatilityVSStability of the object's composition

Solution Approach 1:

The recurrent parent genome is recovered through multiple backcrossing generations before final selection, ensuring that the genetic background is stabilized and representative of the desired morphological and physiological characteristics. This preliminary restoration of the recurrent parent genome prevents instability in non-target traits.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The breeding program applies selection pressure locally at specific genetic loci where herbicide tolerance traits are introduced, while allowing the rest of the genome to maintain the stable characteristics of the recurrent parent. This localized approach to trait introduction minimizes disruption to overall variety stability.

Inventive Principle:
Principle #3Local quality

Data Source

PatentUS12543691B2Soybean variety 01106526
Publication Date: 2026.02.10 MONSANTO TECHNOLOGY LLC

AI summary

The invention relates to the soybean variety designated 01106526. Provided by the invention are the seeds, plants and derivatives of the soybean variety 01106526. Also provided by the invention are tissue cultures of the soybean variety 01106526 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety 01106526 with itself or another soybean variety and plants produced by such methods.