Germinated Fermented Soybean Extract for Climacteric Symptom Relief
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Solution Overview
Problem
Current treatments for climacteric symptoms, such as osteoporosis and skin changes, often involve hormone replacement therapy with side effects, necessitating a safer and more effective natural therapeutic agent.
Innovation Solution
A germinated and fermented bean extract rich in coumestrol is developed for use in pharmaceutical, health food, and cosmetic compositions to address climacteric symptoms, improving bone density, skin elasticity, and skin hydration, while minimizing side effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If hormone replacement therapy is used to treat climacteric symptoms, then treatment effectiveness is improved, but side effects such as increased cancer risk, headache, and weight gain occur
Solution Approach 1:
The patent replaces long-term hormone replacement therapy with a natural plant extract composition that provides temporary but effective symptom relief without the cumulative side effects of prolonged hormone administration. The extract acts as a short-term therapeutic alternative that addresses climacteric symptoms without causing cancer risk or other serious side effects
Solution Approach 2:
The patent changes the chemical composition parameters by using plant extracts containing phytoestrogens and other bioactive compounds instead of synthetic hormones. This parameter change allows the treatment to maintain estrogenic activity while avoiding the harmful side effects associated with conventional hormone replacement therapy
2Object-affected harmful factors
If natural therapeutic agents are developed to avoid side effects, then safety is improved, but treatment effectiveness may be reduced
Solution Approach 1:
The patent uses a composite composition containing multiple plant extracts including Pueraria mirifica, Pueraria lobata, and other botanicals. This composite approach combines the synergistic effects of different phytoestrogens and bioactive compounds to achieve treatment effectiveness comparable to hormone replacement therapy while maintaining the safety profile of natural ingredients
Solution Approach 2:
The natural plant extract composition provides multiple therapeutic functions simultaneously - it addresses hot flashes, mood disturbances, bone density loss, and other climacteric symptoms through a single multi-component formulation, making the natural agent as effective as conventional therapy across multiple symptom domains
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The germinated and fermented bean extract effectively relieves weight gain, recovers bone density, improves skin thickness and elasticity, and reduces transepidermal water loss, with enhanced estrogen activation and collagen synthesis, offering a safer alternative with fewer side effects.
Implementation Method 1
fermenting the germinated bean with Aspergillus oryzae
Data Source
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AI summary
The present invention relates to a composition for, inter alia, preventing menopausal disease comprising a soybean extract comprising coumestrol as an active ingredient, and more specifically relates to a composition for, inter alia, preventing menopausal disease comprising a germinated and fermented soybean extract comprising coumestrol as an active ingredient.