Soybean Resistance Loci Introgression for Asian Rust Control

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

There is a need for novel resistance genes to control soybean pathogens such as Phytophthora and Asian Soybean rust, which cause significant yield losses in soybean crops, and existing methods are inadequate in providing effective pathogen resistance in commercial soybean plants.

Innovation Solution

Introduction of chromosome intervals and loci from Glycine tomentella into Glycine max lines through embryo rescue and marker-assisted breeding to confer resistance to Asian soybean rust, utilizing specific chromosomal intervals and SNPs associated with resistance.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional breeding methods are used to introduce disease resistance, then breeding time and resource investment are reduced, but the effectiveness and precision of introducing specific resistance genes are insufficient

Engineering Contradiction:

Improvepathogen resistance effectivenessVSAvoidbreeding time

Core Design Contradiction:

ReliabilityVSLoss of time

Solution Approach 1:

The patent replaces conventional mechanical breeding methods with marker-assisted selection (MAS) technology. Specific molecular markers (e.g., SNPs, SSRs) are used to identify and track resistance genes during breeding, enabling precise selection of plants carrying desired resistance traits without relying on time-consuming phenotypic observation and manual selection processes

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent introduces molecular markers as intermediaries between the resistance genes and the breeding process. These markers serve as detectable indicators that allow breeders to indirectly select for resistance genes, facilitating the introduction of specific resistance traits from wild relatives or resistant varieties into commercial soybean cultivars more efficiently

Inventive Principle:

Principle #24Intermediary (Mediator)

2Reliability

If existing resistance genes are used in commercial soybean plants, then pathogen resistance is provided, but the resistance becomes ineffective against evolving pathogens over time

Engineering Contradiction:

Improvepathogen resistanceVSAvoidresistance durability

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent segments the resistance trait introduction process into distinct molecular levels, utilizing multiple independent molecular markers to track different resistance genes or alleles. This allows for the introduction of stacked resistance genes or alternative resistance mechanisms that can provide broader and more durable protection against evolving pathogens

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The patent changes the parameter of gene selection by using molecular markers to identify and select for specific resistance gene variants or alternative resistance genes that may not be detectable through conventional phenotypic screening. This enables the introduction of resistance traits with different mechanisms or specificities, enhancing adaptability to pathogen evolution

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentUS12509736B2Genetic loci associated with disease resistance in soybeans

Publication Date: 2025.12.30 SYNGENTA CROP PROTECITON AG

AI summary

The present invention relates to methods and compositions for identifying, selecting and/or producing a Disease resistant soybean plant or germplasm using markers, genes and chromosomal intervals derived from Glycine tomentella PI441001, PI441008, PI446958, PI509501, PI583970, or PI483224. A soybean plant or germplasm that has been identified, selected and/or produced by any of the methods of the present invention is also provided. Disease resistant soybean seeds, plants and germplasms are also provided.