Soybean SCEL-1 Extract Reduces Inflammation via Flavonoid Ratios
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Solution Overview
Problem
There is a demand for a new soybean cultivar or composition with enhanced inflammation prevention or improvement capabilities compared to existing soybeans, as current soybean extracts do not effectively address inflammation caused by external or internal stressors.
Innovation Solution
A composition containing an extract from the soybean Glycine max (L.) Merrill cultivar SCEL-1, which includes cyanidin-3-O-glucoside, procyanidin B2, and epicatechin at specific ratios, is used to prevent or improve inflammation by administering it to a subject, either orally or topically, utilizing an extraction process with water or C1-C6 alcohol.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a new soybean cultivar with enhanced inflammation prevention capabilities is developed, then the effectiveness in preventing inflammation is improved, but the complexity of cultivar development and extraction process increases
Solution Approach 1:
The patent applies parameter changes by selectively breeding soybean plants to achieve specific concentration ratios of flavonoid compounds (cyanidin-3-O-glucoside, procyanidin B2, and epicatechin) in the seeds. The invention targets specific quantitative parameters of these compounds to create a cultivar with enhanced anti-inflammatory properties, thereby improving inflammation prevention effectiveness through controlled chemical composition changes.
Solution Approach 2:
The patent employs extraction principles by developing a standardized extraction process that isolates and concentrates the active flavonoid compounds from the soybean seeds. This extraction method selectively retrieves the beneficial compounds (cyanidin-3-O-glucoside, procyanidin B2, and epicatechin) while removing unwanted substances, thereby creating a purified composition with enhanced anti-inflammatory activity.
2Reliability
If the concentration of procyanidin B2 and epicatechin is increased in the soybean seed, then the anti-inflammatory activity is improved, but the difficulty of achieving and maintaining specific compound ratios increases
Solution Approach 1:
The patent applies parameter changes by establishing specific target ratios for cyanidin-3-O-glucoside, procyanidin B2, and epicatechin in the soybean seed composition. The invention controls the concentration parameters of these compounds through selective breeding and cultivation conditions, achieving a precise balance that maximizes anti-inflammatory activity while maintaining reproducibility.
Solution Approach 2:
The patent employs feedback mechanisms by implementing analytical methods to monitor and measure the concentrations of flavonoid compounds in the soybean seeds during the breeding and cultivation process. This feedback allows for real-time adjustment of cultivation conditions and selection criteria to maintain the desired compound ratios, ensuring consistent anti-inflammatory activity.
3Quantity of substance
If an extraction process using water or C1-C6 alcohol is performed on the soybean seed, then the obtainment of active ingredients is improved, but the loss of time and energy in the extraction process increases
Solution Approach 1:
The patent applies parameter changes by optimizing extraction conditions including solvent type, temperature, time, and solvent-to-material ratio. The invention determines the optimal parameters that maximize the yield of active ingredients (cyanidin-3-O-glucoside, procyanidin B2, and epicatechin) while minimizing energy consumption, achieving efficient extraction with reduced resource loss.
Solution Approach 2:
The patent employs the principle of using simple, readily available solvents (water and common C1-C6 alcohols like ethanol or methanol) for the extraction process. These inexpensive and easily disposable solvents replace complex or expensive extraction systems, reducing both the cost and energy consumption of the extraction process while maintaining effective recovery of active ingredients.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively reduces and treats inflammation in skin and lung tissues by significantly reducing reactive oxygen species and improving conditions such as atopic dermatitis and skin inflammation induced by ultraviolet rays, with the soybean cultivar SCEL-1 exhibiting higher levels of procyanidin B2 and epicatechin compared to standard cultivars.
Implementation Method 1
the ethanol extract of the wild-type soybean has antioxidative activity
Implementation Method 2
an extract obtained by performing an extraction process on a seed of soybean Glycine max (L.) Merrill cultivar SCEL-1 by using water, C1-C6 alcohol, or a mixture thereof
Data Source
AI summary
Provided are a composition for preventing or improving inflammation, the composition including an extract of a seed of soybean Glycine max (L.) Merrill cultivar SCEL-1, and a method of preventing occurrence of inflammation in a subject or improving inflammation in a subject, the method including injecting the composition to a subject.