Soybean Stink Bug Control Using GABA Channel Antagonists

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Stink bugs, particularly the brown stinkbug Euschistus heros, are difficult to manage with existing insecticides due to increasing resistance, causing significant economic damage to soybean crops and facilitating fungal diseases and physiological disorders.

Innovation Solution

The use of gamma-aminobutyric acid (GABA)-gated chloride channel antagonists with a partially saturated heterocycle substituted by a haloalkyl substituent and aromatic or heteroaromatic rings, such as compounds of formula I, effectively controls stink bugs, including resistant strains.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If pyrethroid insecticides are used to control stink bugs, then control effectiveness is improved, but insecticide resistance develops

Engineering Contradiction:

Improvecontrol effectivenessVSAvoidinsecticide resistance

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent changes the chemical parameter of the insecticide by introducing fluorine atoms at specific positions (R2 is chlorodifluoromethyl or trifluoromethyl; R3 is bromo, chloro, fluoro or trifluoromethyl) in the GABA-gated chloride channel antagonist structure. This molecular modification creates new insecticides with improved effectiveness against resistant stink bug populations while maintaining the original mechanism of action.

Inventive Principle:

Principle #35Parameter changes

2Reliability

If organophosphates or endosulfan are used to control stink bugs, then control is achieved, but management difficulty increases

Engineering Contradiction:

Improvecontrol effectivenessVSAvoidmanagement ease

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent modifies the chemical parameters of GABA-gated chloride channel antagonists by introducing specific haloalkyl substituents and aromatic rings, creating compounds with optimized efficacy and reduced management complexity compared to organophosphates and endosulfan.

Inventive Principle:

Principle #35Parameter changes

3Reliability

If existing insecticides are used, then initial control is effective, but resistance-related challenges arise

Engineering Contradiction:

Improvecontrol effectivenessVSAvoidresistance durability

Core Design Contradiction:

ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The patent changes the chemical structure parameters of the insecticide by incorporating fluorinated groups (R2 is chlorodifluoromethyl or trifluoromethyl) and various halogenated aromatic rings, creating molecules that maintain long-term effectiveness against stink bugs without developing resistance.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

These compounds provide superior control over stink bugs, safeguarding soybean crops by reducing infestation and preventing resistance-related challenges.

Implementation Method 1

Compounds that are insecticidally, acaricidally, nematicidally and/or moluscicidally active by antagonism of the gamma-aminobutyric acid (GABA)-gated chloride channel

Methodology Applied

Scientific EffectGABA-gated chloride channel antagonism:

Data Source

PatentUS12446583B2Methods of pest control in soybean

Publication Date: 2025.10.21 SYNGENTA CROP PROTECITON AG

AI summary

Methods of controlling pests on soybean plants, comprising: applying to a crop of soybean plants, the locus thereof, or propagation material thereof, a compound of formula (Ia),wherein X1, R1, R4, R5, *, and **, as defined in claim 1, wherein the soybean plants are Bt plants.