SPARC Antibody Immuno-inhibition for Fish Feed Conversion
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Solution Overview
Problem
The fish culture industry faces challenges in improving the development rate and reducing the feed conversion rate of Epinephelus spp., which are essential for cost control and efficiency, as current methods are hindered by high mortality rates and inefficient feed utilization.
Innovation Solution
The method involves immuno-inhibiting the function of Secreted Protein Acidic and Rich in Cysteine (SPARC) and Myostatin in vertebrates through specific antibodies or fragments, administered via feed compositions or bioencapsulated in shrimp, to lower the feed conversion rate and enhance growth rates.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If traditional fish culture methods are used for Epinephelus spp., then the culture process is simple and easy to operate, but the development rate is slow and culture time is long (8-12 months)
Solution Approach 1:
The patent uses antibodies against SPARC and myostatin as intermediary substances to block the function of these growth-regulating proteins. The antibodies act as mediators that bind to SPARC and myostatin, preventing them from exerting their normal inhibitory effects on fish growth, thereby accelerating development rate without fundamentally changing the culture system
Solution Approach 2:
The patent changes the biochemical parameters of the fish culture system by introducing antibodies that alter the protein expression levels and functional activity of SPARC and myostatin. This biochemical parameter change leads to accelerated growth rate and reduced culture time while maintaining the overall simplicity of the culture method
2Productivity
If traditional feed is used for fish culture, then the feed composition is simple and cost-effective, but the feed conversion rate is high (inefficient feed utilization)
Solution Approach 1:
The patent introduces antibodies as intermediary substances that bind to SPARC and myostatin proteins in the fish body. These antibodies mediate the inhibition of growth-regulating proteins, leading to improved feed utilization efficiency and lower feed conversion rates without requiring changes to the feed composition itself
Solution Approach 2:
The patent changes the physiological parameters of feed utilization by blocking SPARC and myostatin function with antibodies. This results in improved metabolic efficiency and better conversion of feed to body mass, reducing the total feed amount required while maintaining simple feed composition
3Reliability
If traditional culture methods are used, then the operation is simple and management is easy, but mortality rate is high due to viral and bacterial infections
Solution Approach 1:
The patent uses antibodies as intermediary protective agents that specifically bind to and neutralize SPARC and myostatin. This targeted intervention reduces mortality and improves survival rates without introducing complex management systems or multiple intervention strategies
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach effectively reduces the feed conversion rate by 5-42% compared to control groups, leading to improved growth rates and reduced cultural risks, thereby enhancing the efficiency and productivity of fish culture.
Implementation Method 1
immuno-inhibiting the function of secreted protein acidic and rich in cysteine (SPARC) in the vertebrate by feeding the vertebrate with a feed composition comprising a secreted protein acidic and rich in cysteine, a fragment of secreted protein acidic and rich in cysteine, an anti-secreted protein acidic and rich in cysteine antibody, or an anti-fragment of secreted protein acidic and rich in cysteine antibody
Implementation Method 2
a feed conversion rate defined as the mass of the feed eaten divided by the body mass gain of the vertebrate
Data Source
AI summary
The present invention provides a method for lowering the feed conversion rate in a vertebrate comprising inhibiting the function of secreted protein acidic and rich in cysteine (SPARC), wherein the feed conversion rate is defined as the mass of the feed eaten divided by the body mass gain.