Spatially Variant Deformation Algorithm for Medical Image Registration
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Solution Overview
Problem
Current deformation algorithms in image registration for medical applications have a constant flexibility model, which fails to accurately account for varying movements of different structures within the human body, such as the lung during a breathing cycle, leading to inaccuracies in image alignment.
Innovation Solution
Implementing a spatially variant deformation algorithm that includes a flexibility model and smoothing model with constraints or scalars dependent on location and direction, allowing for more realistic representation of feature movements and improved image registration accuracy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a constant flexibility model is used in deformation algorithms, then the algorithm is simpler and faster to compute, but the accuracy of image registration deteriorates because it cannot account for varying movements of different structures
Solution Approach 1:
The patent applies local quality by making the flexibility model spatially variant, where different regions of the image have different flexibility characteristics. The flexibility model is divided into multiple regions, each with its own flexibility parameters that are optimized independently. This allows the algorithm to account for varying movements of different structures (e.g., lung tissue during breathing) while maintaining computational efficiency through region-based processing.
2Measurement precision
If a spatially variant flexibility model is implemented, then image registration accuracy improves by accounting for spatial dependencies, but computation time increases
Solution Approach 1:
The patent segments the image into multiple regions, each with its own flexibility model parameters. This segmentation allows the complex spatially variant flexibility model to be computed efficiently by processing each region independently. The deformation algorithm applies different flexibility constraints to different regions based on their anatomical characteristics, achieving high accuracy while managing computation time through parallelizable region-based processing.
3Productivity
If existing deformation algorithms are used, then the processing speed is fast (on the order of minutes), but the flexibility model is constant and fails to accurately represent movements of structures like the lung during breathing
Solution Approach 1:
The patent introduces dynamics by making the flexibility model adaptive and spatially variant rather than static and constant. The flexibility parameters are dynamically adjusted for different regions of the image based on anatomical information and movement characteristics. This dynamic flexibility model can accurately represent biological structures like the lung during breathing, while maintaining processing speeds compatible with clinical workflows through optimized computational methods.
Data Source
AI summary
Disclosed are systems for and methods of registering (i.e., aligning) a deformable image with a reference image subject to a spatially variant flexibility model and/or a non-Gaussian smoothing model. These systems and methods allow for the consideration of differences between the ways in which structures of interest may move within a patient. The registration includes modifying the deformable image to match similar features in the reference image. The systems include a deformation engine configured for performing a deformation algorithm subject to the spatially variant flexibility and/or smoothing models.


