sPDNF Receptor Binding for Inflammation Control

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Solution Overview

Problem

Current methods for treating or preventing inflammation are inadequate, particularly in conditions like cardiomyopathies, heart failure, and inflammatory diseases of the liver and gastrointestinal tract, where excessive inflammation leads to tissue damage and there is a need for effective regenerative strategies.

Innovation Solution

The use of soluble parasite-derived neurotrophic factor (sPDNF) or its fragments, which bind to TrkA and TrkC receptors, to decrease inflammation, promote stem cell proliferation and mobilization, and increase expression of anti-inflammatory factors in non-neuronal tissues such as the heart, liver, and gastrointestinal tract.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If current methods for treating or preventing inflammation are used, then inflammation can be partially controlled, but they are inadequate for excessive inflammation causing tissue damage

Engineering Contradiction:

Improveeffectiveness of inflammation treatmentVSAvoidtissue damage from excessive inflammation

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent uses sPDNF as an intermediary substance that mediates between the inflammatory response and tissue damage. sPDNF binds to TrkA and TrkC receptors on immune cells and stem cells, modulating their activity to reduce excessive inflammation while promoting tissue regeneration, thus protecting against tissue damage without completely suppressing the inflammatory response

Inventive Principle:

Principle #24Intermediary (Mediator)

2Reliability

If regenerative strategies are implemented for heart failure, then tissue repair can be promoted, but effective strategies are currently lacking

Engineering Contradiction:

Improveeffectiveness of regenerative therapyVSAvoidavailability of regenerative options

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent demonstrates that sPDNF has multiple functions: it reduces inflammation by modulating immune cell activity, promotes stem cell proliferation and differentiation, and enhances tissue regeneration. This multi-functionality makes sPDNF a versatile therapeutic agent applicable to various inflammatory conditions affecting different organs including heart, liver, and gastrointestinal tract

Inventive Principle:

Principle #6Universality (Multi-functionality)

3Productivity

If stem cell proliferation is promoted, then tissue regeneration is enhanced, but current methods lack effective approaches

Engineering Contradiction:

Improvestem cell proliferation rateVSAvoideffectiveness of stem cell expansion

Core Design Contradiction:

ProductivityVSReliability

Solution Approach 1:

The patent utilizes feedback mechanisms where sPDNF binding to TrkA and TrkC receptors activates signaling pathways that promote stem cell proliferation and self-renewal. The sustained presence of sPDNF creates a positive feedback loop that continuously stimulates stem cell expansion and differentiation into tissue-specific cells, enhancing regenerative capacity

Inventive Principle:

Principle #23Feedback

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

sPDNF effectively reduces inflammation, promotes tissue regeneration, and increases stem cell numbers and anti-inflammatory factors, providing a therapeutic approach for treating cardiac, hepatic, and gastrointestinal inflammatory diseases.

Implementation Method 1

soluble parasite-derived neurotrophic factor (sPDNF), or its fragments, which bind to TrkA and TrkC receptors

Methodology Applied

Scientific EffectReceptor binding:

Data Source

PatentUS10272138B2Methods of generating anti-inflammatory stem cells

Publication Date: 2019.04.30 TUFTS UNIV

AI summary

The invention provides compositions and methods for treating inflammatory diseases, such as cardiac or hepatic inflammatory diseases, involving the use of parasite-derived neurotrophic factor (PDNF), or fragment of PDNF.