Specific Tetrapeptide Compositions for Skin Aging and ROS Control
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Solution Overview
Problem
There is a need for compositions and methods to effectively treat, prevent, minimize, diminish, or reverse the symptoms of natural or premature skin aging, including loss of firmness, elasticity, wrinkling, hyperpigmentation, and skin thickness, which current over-the-counter treatments have not adequately addressed.
Innovation Solution
Compositions containing specific peptides, such as pGlu-X1-X2-X3—OH or their derivatives, where X1 is a polar amino acid, X2 is aromatic or hydrophobic, and X3 is positively charged or polar, are used topically to reduce reactive oxygen species and enhance epidermal cell viability, thereby improving skin firmness, elasticity, and reducing signs of aging.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional over-the-counter topical creams and moisturizers are used, then basic skin hydration is maintained, but they fail to effectively treat or reverse signs of aging such as loss of firmness, elasticity, and wrinkles
Solution Approach 1:
The patent changes the chemical parameters of the formulation by incorporating specific peptides (pGlu-X1-X2-X3-OH) with defined amino acid sequences and properties. These peptides have specific molecular structures with polar, aromatic/hydrophobic, and positively charged residues that enable them to attenuate ROS formation and enhance cell viability, thereby effectively treating aging symptoms while maintaining formulation feasibility
Solution Approach 2:
The patent uses composite material principles by combining peptides with dermatologically acceptable carriers to create a formulation that integrates multiple functional components. The peptide-carrier composite system delivers the active peptide ingredient while maintaining stability and skin compatibility, resolving the contradiction between effectiveness and ease of manufacture
2Manufacturing precision
If peptides are used to attenuate ROS formation and enhance cell viability, then skin firmness, elasticity, and thickness are improved, but the formulation requires specific peptide structures and concentrations
Solution Approach 1:
The patent applies local quality by specifying particular amino acid residues at particular positions in the peptide sequence (X1 as polar, X2 as aromatic or hydrophobic, X3 as positively charged or polar). This localized structural specification at critical positions enables the peptide to effectively attenuate ROS and enhance cell viability without requiring complete control of the entire molecular structure, thereby reducing overall composition complexity while maintaining manufacturing precision where it matters most
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The peptides effectively improve skin firmness, elasticity, reduce wrinkles, hyperpigmentation, and increase skin thickness by attenuating ROS formation and enhancing cell viability, providing a cosmetic benefit in treating and preventing aging-related skin conditions.
Implementation Method 1
peptides denoted ZEP3 and ZEP4 or salts thereof attenuate the formation of reactive oxygen species (ROS) and increase viability of epidermal cells under stress conditions
Implementation Method 2
peptides denoted ZEP3 and ZEP4 or salts thereof attenuate the formation of reactive oxygen species (ROS) and increase viability of epidermal cells under stress conditions
Data Source
AI summary
Compositions comprising specific tetrapeptides, for use in treating, preventing, minimizing, diminishing or reversing various signs of aging of the skin are provided. The compositions are useful in improving the firmness or elasticity of skin, smoothing of fine-lines or wrinkles, reducing skin pores and hyperpigmentation, and increasing skin thickness, radiance and/or softness.