Specimen Analyzing Apparatus Interference Compensation
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Solution Overview
Problem
Existing specimen analyzing apparatuses face difficulties in performing accurate optical measurements due to interference substances like hemoglobin, lipid, and bilirubin in plasma, serum, or urine specimens, leading to reduced analytical efficiency.
Innovation Solution
A specimen analyzing method and apparatus that involves sucking a specimen into a first container for optical measurement, then mixing it with a reagent in a second container to create a measurement sample, allowing for analysis and controlling the analysis process based on the optical measurement results to mitigate the effects of interference substances.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If optical measurement is performed directly on the specimen, then measurement speed is improved, but measurement precision deteriorates due to interference substances
Solution Approach 1:
The patent applies preliminary action by performing optical measurement on the specimen before adding reagents to prepare the measurement sample. The control unit determines the presence of interference substances (hemoglobin, lipid, bilirubin) through this preliminary optical measurement, enabling early identification and compensation strategies to be implemented before the main measurement process begins
Solution Approach 2:
The patent introduces an intermediary measurement process using multiple wavelengths of light to detect interference substances. By measuring optical absorption at specific wavelengths (including 405nm for hemoglobin, 575nm for bilirubin, and 900nm for lipid), the system creates an intermediate assessment of specimen quality that mediates between the raw specimen and the final measurement, allowing for mathematical compensation of interference effects
2Measurement precision
If separate hemolysis, chyle and icterus measuring apparatus is provided, then measurement precision is improved, but device complexity increases
Solution Approach 1:
The patent merges the interference substance measurement function into the main specimen analyzing apparatus. The same optical measurement system used for analyzing measurement samples is also used to measure the specimen before reagent addition, determining presence of hemoglobin, lipid, and bilirubin. This integration eliminates the need for separate hemolysis, chyle and icterus measuring apparatus while maintaining measurement precision
Solution Approach 2:
The optical measurement system in the specimen analyzing apparatus is designed to serve multiple functions: it can measure the specimen directly to detect interference substances, and it can measure the measurement sample after reagent addition for the actual analytical measurement. This multi-functionality allows a single device to perform both interference detection and analytical measurement, reducing overall system complexity
3Measurement precision
If specimen is not analyzed when interference substances are present, then measurement precision is maintained, but productivity decreases
Solution Approach 1:
The patent implements feedback by using the control unit to analyze optical measurement results and determine the presence and concentration of interference substances. Based on this feedback information, the system automatically adjusts the measurement process, applying mathematical compensation algorithms to correct for interference effects. This allows the apparatus to maintain measurement precision while continuing to process specimens that would otherwise be rejected
Solution Approach 2:
The patent changes measurement parameters by performing optical measurements at multiple different wavelengths. By measuring absorbance at specific wavelengths (405nm, 575nm, 900nm, and others) and analyzing the spectral characteristics, the system can distinguish between different interference substances and their concentrations, enabling parameter-based compensation to maintain measurement precision
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables accurate analysis by identifying and accounting for interference substances, thereby improving the analytical efficiency and reliability of specimen testing.
Implementation Method 1
a light of a specific wavelength is absorbed
Implementation Method 2
analyzing scattered light or transmitted light from the analytical sample
Data Source
AI summary
A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.