Specimen Measurement Apparatus Dynamic Step Timing Control

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

Conventional immunological tests face inefficiencies due to fixed time allocations for steps, leading to prolonged test durations as steps do not always progress smoothly, resulting in unnecessary extended testing times.

Innovation Solution

A specimen measurement apparatus and method that utilize a detector and control circuit to control transition timing between steps based on electromagnetic wave detection, optimizing the measurement flow by adjusting timing according to the reaction conditions in the reaction container, which includes a reaction case with an optical waveguide and magnetic microparticles for antigen-antibody reactions.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If fixed time allocation for each step is used to guarantee measurement sensitivity, then measurement reliability is improved, but measurement time is extended unnecessarily

Engineering Contradiction:
Improvemeasurement sensitivityVSAvoidmeasurement time
Core Design Contradiction:
ReliabilityVSLoss of time

Solution Approach 1:

The patent applies dynamics by transitioning from fixed, uniform time allocation for each test step to dynamic time adjustment based on actual reaction progress. The system monitors electromagnetic wave signals in real-time and automatically adjusts the duration of each step according to the detected reaction state, allowing the measurement process to adapt its timing to the specific kinetics of each test substance while maintaining sufficient sensitivity.

Inventive Principle:
Principle #15Dynamics

Solution Approach 2:

The patent implements feedback by continuously detecting electromagnetic wave signals during the test process and using this information to control the timing of subsequent steps. The system measures the state of the reaction mixture at each step, compares it against expected progression patterns, and adjusts the timing of wash steps, incubation periods, and signal detection accordingly, creating a closed-loop control system that optimizes both speed and sensitivity.

Inventive Principle:
Principle #23Feedback

2Stability of the object's composition

If uniform time setting for all test items is applied, then measurement consistency is maintained, but test efficiency is reduced due to unnecessary extended duration

Engineering Contradiction:
Improvemeasurement consistencyVSAvoidtest efficiency
Core Design Contradiction:
Stability of the object's compositionVSProductivity

Solution Approach 1:

The patent applies parameter changes by dynamically modifying the time parameter for each test step based on the detected reaction progress. Instead of using a single uniform time setting for all test items, the system adjusts timing parameters in real-time according to the specific kinetic characteristics of each antigen-antibody reaction, allowing faster reactions to proceed more quickly while ensuring sufficient time for slower reactions, thereby maintaining consistency across different test items while improving overall efficiency.

Inventive Principle:
Principle #35Parameter changes

3Device complexity

If fixed step timing is used to simplify control, then device complexity is reduced, but measurement optimization is lost

Engineering Contradiction:
Improvecontrol simplicityVSAvoidmeasurement optimization
Core Design Contradiction:
Device complexityVSProductivity

Solution Approach 1:

The patent replaces the mechanical/time-based control system with an electromagnetic field-based detection and control system. Instead of relying on pre-programmed fixed timing sequences, the system uses electromagnetic wave detection to monitor reaction progress and automatically adjusts timing based on real-time measurements. This substitution of mechanical timing control with electromagnetic sensing and feedback control enables optimization without significantly increasing operational complexity.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach allows for reduced measurement time by dynamically controlling step transitions, ensuring efficient progression of the test based on real-time reaction progress, thereby shortening the overall testing duration without compromising accuracy.

Implementation Method 1

a reaction case with an optical waveguide

Methodology Applied
Scientific EffectOptical waveguide: Waveguide (optics)

Implementation Method 2

magnetic microparticles for antigen-antibody reactions

Methodology Applied
Scientific EffectMagnetic field interaction: Magnetic Field

Data Source

PatentUS9897599B2Specimen measurement apparatus and specimen measurement method
Publication Date: 2018.02.20 TOSHIBA MEDICAL SYST CORP
  • US9897599B2 patent drawing
  • US9897599B2 patent drawing
  • US9897599B2 patent drawing

AI summary

According to one embodiment, a specimen measurement apparatus includes a detector and a control circuit, and is configured to perform a plurality of steps to measure the properties of a test substance retained in a reaction container. The detector outputs electromagnetic waves to the reaction container and detects the electromagnetic waves that vary according to the state in the reaction container. The control circuit controls transition timing between steps of the plurality of steps based on the detection result of the electromagnetic waves obtained by the detector.