Spectral-Filter Chromatography for Rapid Component Quantification
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Solution Overview
Problem
Existing methods require long separation times in chromatography to avoid overlapping peaks, hindering fast and accurate quantification of specific components in mixtures.
Innovation Solution
A method involving chromatography with a filter to extract specific component measurements by deriving index values from spectra, generating a chromatogram, and quantifying the component based on peak analysis, using a system with a measuring instrument and analyzer.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If chromatography is performed with low mobile phase flow rate to achieve long separation time, then peak separation improves and measurement accuracy increases, but measurement time increases and productivity decreases
Solution Approach 1:
The patent applies preliminary action by performing peak separation using chromatography at low flow rate only once to obtain reference peak information, then using this pre-acquired information to enable rapid quantification without repeated slow separations. The reference peak data is stored and reused for multiple measurements.
Solution Approach 2:
The patent replaces the mechanical separation process with information processing. Instead of relying on physical peak separation for every measurement, the system uses previously acquired peak information and applies it through data processing to achieve quantification, substituting the need for repeated mechanical separation.
2Productivity
If chromatography is performed with high mobile phase flow rate to achieve fast measurement, then productivity improves and measurement time decreases, but peak separation deteriorates and measurement accuracy decreases
Solution Approach 1:
The system performs the accurate separation action in advance at low flow rate to build a reference database of peak positions and characteristics. This preliminary accurate measurement enables subsequent rapid measurements at high flow rates without sacrificing accuracy, as the reference data compensates for the reduced separation quality.
Solution Approach 2:
The patent creates a copy of the peak information obtained from slow chromatography and uses this copied data for rapid quantification. Instead of repeatedly performing slow separations, the system copies the essential peak characteristics and applies them to enable fast measurements that maintain accuracy.
3Measurement precision
If long separation time is used to prevent peak overlap, then component resolution improves and quantification accuracy increases, but analysis time increases and efficiency decreases
Solution Approach 1:
The patent performs the time-consuming peak separation action preliminarily to establish reference peak information, then uses this pre-established information for rapid component identification and quantification. The heavy lifting of separation is done once, and the results are reused to avoid repeated time loss.
Solution Approach 2:
The patent substitutes the mechanical separation process with information-based component identification. Once peak positions are known from preliminary separation, the system uses data processing and pattern recognition to identify and quantify components without requiring repeated mechanical separation, thereby reducing analysis time while maintaining resolution.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables fast and accurate quantification of specific components in mixtures by applying a filter to chromatograms, allowing for high-speed measurement without lengthy separation processes.
Implementation Method 1
obtaining a measurement spectrum at each of a plurality of points in time by analyzing the measurement sample with chromatography
Implementation Method 2
deriving an index value at each point of the plurality of points in time, by applying a filter for extracting the specific component, to the measurement spectrum at the point of the plurality of points in time
Data Source
AI summary
Provided is a method for quantifying a specific component contained in a measurement sample. The method includes: obtaining a measurement spectrum at each of a plurality of points in time by analyzing the measurement sample with chromatography; deriving an index value at each point of the plurality of points in time, by applying a filter for extracting the specific component, to the measurement spectrum at the point of the plurality of points in time; obtaining a chromatogram by arranging one or more index values at respective one or ones of the plurality of points in time; and quantifying the specific component based on a peak of the chromatogram.