SPFS Detection Device Angle Adjustment via Optical Filter
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Solution Overview
Problem
Detection devices utilizing Surface Plasmon-Field Enhanced Fluorescence Spectroscopy (SPFS) face challenges in determining the enhancement angle for maximizing plasmon scattering light without disrupting the optical filter in the light reception optical system, affecting detection sensitivity and accuracy.
Innovation Solution
A detection device with an angle adjusting section, optical filter, and control section that allows plasmon scattering light to pass through, enabling the determination of the enhancement angle without moving the optical filter, allowing for high sensitivity and accuracy in detecting the presence or amount of a detection object substance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If the optical filter is moved out from the light path to determine the enhancement angle, then the plasmon scattering light detection is improved, but the device complexity and operation complexity increase
Solution Approach 1:
The optical filter is designed to automatically transmit plasmon scattering light at the enhancement angle without requiring manual intervention or mechanical positioning mechanisms. The filter's optical properties enable it to selectively pass the desired wavelength range when light enters at the enhancement angle, eliminating the need for complex moving parts or adjustment mechanisms.
Solution Approach 2:
The optical filter is designed with specific optical parameters (wavelength transmission characteristics) that allow it to automatically differentiate between plasmon scattering light and other light components based on the enhancement angle. By optimizing the filter's transmission spectrum, the system can determine the enhancement angle through the filter's inherent optical properties rather than mechanical adjustment.
2Device complexity
If the optical filter remains in the light path during enhancement angle determination, then the device structure is simplified, but the plasmon scattering light detection sensitivity is reduced
Solution Approach 1:
The optical filter serves as an intermediary element that mediates between the plasmon scattering light and the detector. It is designed to selectively transmit the enhancement angle signal while blocking other wavelengths, enabling accurate enhancement angle determination even when the filter remains in the light path. The filter acts as a wavelength-selective gate that allows the desired signal to pass through.
3Measurement precision
If highly sensitive light sensors such as photomultiplier tube or avalanche photodiode are used, then the fluorescence detection sensitivity is improved, but the device cost increases
Solution Approach 1:
The patent replaces the need for highly sensitive and expensive light sensors with a more economical approach using standard light sensors combined with an optimized optical filter system. By pre-filtering the light to enhance the signal-to-noise ratio before detection, the system achieves high detection sensitivity using less expensive photodetectors, thereby substituting the need for costly photomultiplier tubes or avalanche photodiodes.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables high sensitivity, high accuracy, and high-speed detection of detection object substances while downsizing and reducing the cost of the detection device by determining the enhancement angle without moving the optical filter, thereby improving detection efficiency and reducing complexity.
Implementation Method 1
an optical filter disposed in the light reception optical system, and configured to block a part of plasmon scattering light having a wavelength identical to a wavelength of the excitation light; the optical filter allows a part of the plasmon scattering light and fluorescence emitted from the fluorescence material in the light emitted from the detection chip to pass therethrough
Implementation Method 2
a light receiving sensor configured to detect light emitted from the detection chip when the light irradiation section applies the excitation light to the metal film
Implementation Method 3
an angle adjusting section configured to adjust an incident angle of the excitation light to the metal film to apply the excitation light to the metal film through the prism at a predetermined incident angle
Implementation Method 4
apply excitation light to the metal film through the prism to excite a fluorescence material for labelling a detection object substance on the metal film with localized light based on surface plasmon resonance
Implementation Method 5
excite a fluorescence material for labelling a detection object substance on the metal film with localized light based on surface plasmon resonance, and detect fluorescence emitted from the fluorescence material
Data Source
AI summary
This detection device has a holder, light irradiation unit, angle adjustment unit, light receiving sensor, light receiving optical system, optical filter, and a control unit. The light receiving optical system guides light from a detection chip to the light receiving sensor. The optical filter is disposed in the light receiving optical system, blocks a part of plasmon scattered light, and passes, out of the light emitted from the detection chip, a part of the plasmon scattered light, and fluorescence emitted from a fluorescent material. The light receiving sensor detects the fluorescent light, and the part of the plasmon scattered light, which have been emitted from the detection chip and passed the optical filter. On the basis of the detection results of the plasmon scattered light, the control unit controls the angle adjustment unit, and adjusts the incident angle of the excitation light to a predetermined incident angle.