Spherical Particle Therapeutic Beverage for Stable Drug Delivery
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Solution Overview
Problem
Current pharmaceutical dosage forms, such as tablets and capsules, face challenges with stability, bioavailability, and patient compliance due to swallowing issues, and existing aqueous solutions often lack stability and require costly control measures to maintain API integrity.
Innovation Solution
Development of a stable pharmaceutical formulation in the form of a single dose therapeutic beverage containing spherical- or spheroidal-shaped particles suspended in a liquid medium, where the API is partitioned between the particles and the liquid, providing immediate and delayed release, using gelling agents like gellan gum and alginate, and agents for spherification.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If tablets or capsules are used for drug administration, then the desired therapeutic effect is achieved, but patient compliance deteriorates due to swallowing difficulties
Solution Approach 1:
The patent transforms the physical state of the pharmaceutical composition from solid (tablets/capsules) to liquid (aqueous solution), fundamentally changing the administration method from swallowing to drinking, thereby resolving the swallowing difficulty while maintaining therapeutic efficacy
Solution Approach 2:
The patent divides the pharmaceutical composition into dispersed spherical particles within an aqueous solution, creating a suspension system that maintains drug stability while improving ease of administration through liquid form
2Ease of operation
If aqueous solutions are used to improve ease of ingestion, then patient compliance improves, but API stability deteriorates due to hydrolysis and degradation
Solution Approach 1:
The patent introduces spherical particles as an intermediary carrier that encapsulates the API, protecting it from direct contact with the aqueous environment that would cause hydrolysis, while still allowing controlled release and maintaining stability
Solution Approach 2:
The patent creates a composite system combining spherical particles with specific surface properties and aqueous solution, where the particle matrix provides stability protection while the liquid medium enables easy ingestion
3Ease of manufacture
If conventional aqueous formulations are prepared without controlled deoxygenation, then production costs decrease, but API stability deteriorates due to oxidation
Solution Approach 1:
The patent converts the potentially harmful oxidation effect into a beneficial stability mechanism by designing spherical particles with controlled porosity and surface properties that allow selective gas permeation, protecting the API from oxidation without requiring costly deoxygenation processes
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The formulation enhances bioavailability and stability, improves patient compliance by offering an easy-to-ingest form, and maintains API stability without the need for costly control measures, providing both immediate and sustained drug release.
Implementation Method 1
spherical- and/or spheroidal-shaped particles suspended in a medium, e.g., an aqueous solution
Implementation Method 2
the API is partitioned between the particles and the liquid, providing immediate and delayed release
Data Source
AI summary
Described herein are therapeutic beverages that include a beverage type liquid medium and a plurality of spherical- and/or spheroidal-shaped particles dispersed within the liquid medium, wherein the plurality of the spherical- and/or spheroidal-shaped particles comprise at least one active pharmaceutical ingredient (API) disposed within the plurality of the spherical- and/or spheroidal-shaped particles. Also, described herein are methods of producing the described therapeutic beverages.