Sphingomyelin Collar Matrix for Sustained Atopic Dermatitis Relief

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Solution Overview

Problem

Current treatments for atopic dermatitis in companion animals, such as spot-on pipettes, are inconvenient, costly, and require frequent application, while the effectiveness of using a collar for administering active substances for atopic dermatitis is unproven and may face issues with substance release and distribution.

Innovation Solution

A collar comprising a polymeric matrix and a lipid extract containing sphingomyelins, which provides a controlled release of the active substance over time, reducing the need for frequent application and ensuring broad distribution across the animal's body.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If spot-on pipettes are used to treat atopic dermatitis, then the active substance can be delivered to affected areas, but frequent application (every week) is required which increases cost and inconvenience

Engineering Contradiction:

Improvetreatment effectivenessVSAvoidapplication frequency

Core Design Contradiction:

ReliabilityVSLoss of time

Solution Approach 1:

The active substance is pre-loaded into the collar matrix before use, allowing sustained release over an extended period without requiring frequent reapplication. The collar is prepared in advance with the medicinal substance embedded in its structure, eliminating the need for weekly applications of spot-on pipettes.

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The collar provides continuous release of the active substance over time through its polymeric matrix, maintaining therapeutic levels consistently rather than requiring intermittent dosing. This continuous action ensures sustained treatment effectiveness while reducing the frequency of user intervention.

Inventive Principle:

Principle #20Continuity of useful action

2Area of stationary object

If multiple pipettes are applied to cover various affected areas, then complete coverage is achieved, but the cost and complexity of treatment increases

Engineering Contradiction:

Improvecoverage areaVSAvoidnumber of applications required

Core Design Contradiction:

Area of stationary objectVSDevice complexity

Solution Approach 1:

The collar serves multiple functions simultaneously: it provides sustained release of active substance, ensures broad coverage through the animal's grooming behavior, and eliminates the need for multiple separate applications. A single collar device replaces the need for multiple pipette applications to different body areas.

Inventive Principle:

Principle #6Universality (Multi-functionality)

Solution Approach 2:

The animal itself distributes the active substance across its body through natural grooming behaviors such as licking and scratching. The collar acts as a self-distributing system where the animal's own movements ensure comprehensive coverage of affected areas without requiring manual application to each specific location.

Inventive Principle:

Principle #25Self-service

3Reliability

If steroids or antibiotics are used long-term to treat atopic dermatitis, then symptom relief is achieved, but unwanted side effects occur

Engineering Contradiction:

Improvesymptom reliefVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The invention changes the chemical parameters of the treatment by using alternative active substances embedded in the collar matrix that provide therapeutic effects without the harmful side effects of long-term steroid or antibiotic use. The sustained release mechanism maintains effective concentrations while avoiding the cumulative toxicity associated with prolonged conventional treatment.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The collar effectively reduces lesions and itching associated with atopic dermatitis, showing significant improvement within four weeks and maintaining efficacy for up to eight weeks, with a cost-effective and easy application method.

Implementation Method 1

the collar of the present invention... shows an adequate in vitro kinetic release pattern of the lipid extract

Methodology Applied

Scientific EffectDiffusion: Diffusion

Implementation Method 2

designed for slow and sustained release, providing effective treatment

Methodology Applied

Scientific EffectErosion:

Data Source

PatentUS12611374B2Dermatological collar for non-human animals

Publication Date: 2026.04.28 BIOIBERICA SA

AI summary

The present invention relates to a collar for non-human animals, preferably for companion animals, comprising a polymeric matrix and a lipid extract comprising sphingomyelins. It also refers to the collar for use as a medicine, particularly for use as an adjuvant and for use in the treatment or prevention of atopic dermatitis or allergic dermatitis, as well as in restoring the integrity of the skin during or after an atopic dermatitis or an allergic dermatitis, increasing the hydration and flexibility of the skin, facilitating skin regeneration or reducing itching of the skin.