Sphingosine-1-phosphate Receptor Modulators for Selective Therapeutic Treatment
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Solution Overview
Problem
Current treatments for disorders associated with sphingosine-1-phosphate receptor modulation lack effective and selective modulators, which are crucial for addressing various diseases including cardiovascular diseases, cancers, and inflammatory conditions.
Innovation Solution
Development of novel compounds, specifically represented by Formula I, which act as potent and selective sphingosine-1-phosphate modulators, including receptor agonists, antagonists, and inverse agonists, to treat a wide range of disorders by modulating sphingosine-1-phosphate receptors.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current treatments are used for disorders associated with sphingosine-1-phosphate receptor modulation, then existing therapeutic approaches are maintained, but effective and selective modulators are lacking
Solution Approach 1:
The patent applies parameter changes by systematically varying molecular parameters of the compounds (Formula I) including substituent groups R1-R9, ring structures, and functional groups to optimize both therapeutic effectiveness and receptor modulation selectivity. This involves changing chemical structure parameters to achieve desired pharmacological properties
Solution Approach 2:
The patent applies local quality by introducing specific functional groups and substituent patterns at particular positions in the molecular structure (different R groups at different positions) to achieve selective interaction with specific sphingosine-1-phosphate receptors, thereby enhancing both effectiveness and selectivity simultaneously
2Adaptability or versatility
If novel compounds of Formula I are developed as sphingosine-1-phosphate modulators, then therapeutic benefits across multiple disease areas are achieved, but compound structure complexity increases
Solution Approach 1:
The patent applies universality by designing compounds of Formula I that can function as multiple types of receptor modulators (agonists, antagonists, inverse agonists) depending on the specific molecular configuration, allowing a single compound class to address multiple disease areas including cardiovascular diseases, cancers, and inflammatory conditions
Solution Approach 2:
The patent applies segmentation by dividing the molecular structure into distinct functional segments (R1-R9 substituent groups, core ring structures, linker regions) that can be independently optimized, allowing complex therapeutic functionality to be achieved through modular assembly of structured components
Data Source
AI summary
The present invention relates to novel amine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.