Spinacea oleracea Formulation for Bone Anabolic Effects

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Solution Overview

Problem

Current treatments for osteoporosis and osteoarthritis, such as anti-resorptive therapies, primarily focus on slowing bone loss rather than promoting new bone formation, and often come with undesirable side effects, while there is a need for herbal products that can enhance bone mass and strength to reduce fracture risk and improve osteohealth.

Innovation Solution

A formulation comprising specific flavone compounds from Spinacea oleracea, combined with pharmaceutically acceptable carriers and surfactants, is developed to promote bone anabolic effects, enhance bone mass, and treat bone-related disorders, including osteoporosis and osteoarthritis, through oral administration.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If anti-resorptive therapies (calcium, vitamin D, bisphosphonates, HRT) are used to slow bone loss, then bone resorption rate decreases, but side effects increase (gastrointestinal irritation, thromboembolic diseases, endometrial hyperplasia, breast cancer risk)

Engineering Contradiction:

Improvebone loss preventionVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent uses natural plant extracts (Spinacea oleracea, Dalbergia sissoo) as temporary, renewable sources of osteogenic compounds that can be administered orally without accumulating in the body like synthetic drugs, reducing long-term toxicity risks

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The patent employs natural plant-derived compounds as intermediaries that mediate bone formation through physiological pathways (osteogenic gene expression, BMP signaling) rather than directly inhibiting resorption, thus avoiding the harsh side effects of conventional anti-resorptive agents

Inventive Principle:

Principle #24Intermediary (Mediator)

2Reliability

If hormone replacement therapy is used to prevent bone loss after menopause, then bone mass is maintained, but risk of breast cancer, endometrial hyperplasia, and thromboembolic diseases increases

Engineering Contradiction:

Improvebone mass maintenanceVSAvoidcancer and thromboembolic risk

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent extracts and isolates specific osteogenic compounds from plant sources (flavonoids, terpenoids, alkaloids) that can mimic the bone-protective effects of hormones without the carcinogenic and thrombotic risks associated with exogenous hormone replacement

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The patent uses natural plant extracts as temporary, renewable sources of osteogenic compounds that can be administered orally without accumulating in the body like synthetic drugs, reducing long-term toxicity risks

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

3Reliability

If bisphosphonates are used to treat osteoporosis, then bone resorption is inhibited, but gastrointestinal absorption is poor and irritation occurs

Engineering Contradiction:

Improvebone resorption inhibitionVSAvoidgastrointestinal absorption

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent changes the chemical parameters of bone-active compounds by using naturally occurring plant-derived molecules with optimal solubility, stability, and bioavailability characteristics, eliminating the gastrointestinal absorption problems of bisphosphonates

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

Inventive Principle:

Principle #24Intermediary (Mediator)

4Reliability

If current anti-resorptive agents are used, then bone loss rate is reduced, but new bone formation is not promoted

Engineering Contradiction:

Improvebone loss reductionVSAvoidnew bone formation

Core Design Contradiction:

ReliabilityVSProductivity

Solution Approach 1:

The patent inverts the conventional approach by switching from anti-resorptive therapy to pro-formation therapy, using plant-derived compounds that actively stimulate osteoblast activity and new bone synthesis rather than merely preventing bone breakdown

Inventive Principle:

Principle #13The other way round (Inversion)

Solution Approach 2:

Inventive Principle:

Principle #24Intermediary (Mediator)

Data Source

PatentUS10265297B2Formulation for the prevention and treatment of bone related disorders

Publication Date: 2019.04.23 COUNCIL OF SCI & IND RES

AI summary

The present invention relates to a formulation of Spinacea oleracea useful for the prevention or treatment of osteo-health related disorders. The present invention relates to the field of pharmaceutical formulation that provides extract, fractions, pure compound isolated from natural sources and formulation thereof useful for the prevention and treatment of various medical indications. Further, this invention relates to conditions associated with estrogen dependent or independent diseases (primary/secondary osteoporosis) or syndromes or disorders preferably relating to cartilage such as osteoarthritis caused in humans and animals. Furthermore, this invention relates to achievement of peak bone mass during skeletal growth and health in humans and animals. Particularly, the present invention relates to the processes for the preparation of biologically active extracts, from Spinacea oleracea from the family Amaranthaceae their pharmaceutically acceptable excepients and compositions of the principal aspect of the present invention.