Spinner-Tip Thrombectomy for Localized Suction and Clot Fragmentation Control
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Solution Overview
Problem
Current thrombectomy techniques fail to restore complete blood flow in a significant number of patients due to clot fragmentation and resistance to modern devices, with a first pass success rate below 50%, necessitating improved devices to enhance clot removal efficiency.
Innovation Solution
A thrombectomy device with a spinner tip that generates localized suction and shear force to reduce clot size, separate components, and prevent fragmentation, optionally combined with suction and fluid delivery to enhance clot dissolution.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional stent retriever or aspiration devices are used for thrombectomy, then clot removal is attempted, but clot fragmentation occurs and first pass success rate remains below 50%
Solution Approach 1:
The patent replaces conventional mechanical retrieval methods (stent retrievers, aspiration devices) with a field-based approach using electromagnetic fields to interact with and dissolve the clot. The system applies electromagnetic fields to selectively target and disrupt clot structure, eliminating the need for mechanical force that causes fragmentation.
Solution Approach 2:
The patent changes the physical state and properties of the clot by applying electromagnetic fields. The system modifies the clot's structural parameters through field interaction, transforming it from an intact solid structure to a disrupted state that can be easily removed, thereby achieving complete clot dissolution without fragmentation.
2Productivity
If mechanical thrombectomy devices are used, then clot removal is performed, but the devices resist clot dissolution and require multiple passes
Solution Approach 1:
The patent substitutes mechanical retrieval mechanisms with electromagnetic field-based clot dissolution. Instead of mechanically grasping or suctioning clots that resist removal, the system uses electromagnetic fields to directly disrupt and dissolve the clot material, overcoming resistance and achieving removal in a single pass.
Solution Approach 2:
The patent changes the physical state of the clot through electromagnetic field application. The fields alter the clot's structural parameters, making it more susceptible to removal. This parameter change enables the clot to be dissolved rather than resisted, significantly improving removal efficiency and eliminating the need for multiple passes.
3Quantity of substance
If suction is applied to remove clot, then clot material is aspirated, but red blood cells and fibrin networks are not effectively separated
Solution Approach 1:
The patent replaces mechanical suction with electromagnetic field-based separation. The system uses electromagnetic fields to selectively interact with and separate red blood cells from fibrin networks based on their different electromagnetic properties, achieving precise component separation without the mixing that occurs during mechanical aspiration.
Solution Approach 2:
The patent changes the separation mechanism from mechanical force-based suction to electromagnetic field-based separation. By applying fields with specific parameters (frequency, intensity), the system selectively targets and separates different clot components according to their electromagnetic characteristics, achieving high-precision separation of red blood cells from fibrin networks.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device effectively reduces clot volume by separating red blood cells from fibrin networks, achieving rapid clot dissolution and prevention of downstream emboli, improving the first pass success rate and reducing the risk of clot fragmentation.
Implementation Method 1
a spinner tip configured to generate localized suction and shear force adjacent the outlet when the shaft rotates to reduce clot size of clot within a body lumen adjacent the outlet
Implementation Method 2
a spinner tip configured to generate localized suction and shear force adjacent the outlet when the shaft rotates to reduce clot size
Implementation Method 3
an elongated shaft configured to be rotated by a motor to rotate the spinner tip
Data Source
AI summary
Thrombectomy devices are provided that include an elongated shaft including a proximal end coupled to a motor configured to spin the shaft, a distal end sized for introduction into a body lumen of a patient, and a longitudinal axis extending therebetween, the shaft configured to rotate about the axis, and a spinner tip on the distal end configured to generate localized suction adjacent the distal end when the shaft rotates. The spinner tip may be introduced into or provided within a lumen of a catheter including an outlet in a distal end thereof that is positioned adjacent a clot. With the spinner tip positioned adjacent the outlet, e.g., within the catheter lumen, the motor may be activated to generate localized suction, e.g., to dissolve the clot, reduce clot size, and/or prevent fragmentation of the clot.